318685-32-4Relevant academic research and scientific papers
3-amino -7,8-difluoro-quinoline and wherein the intermediate synthesis method
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Paragraph 0026; 0027; 0028, (2016/10/10)
The invention provides 3-amino-7,8-difluoroquinoline and a synthesis method of an intermediate body of the 3-amino-7,8-difluoroquinoline. 3-amino-7,8-difluoromethylquinoline is prepared by three steps of carrying out substitution reaction on 7,8-difluoroquinoline, carrying out condensation reaction on 3-bromine-7,8-difluoroquinoline and carrying out amino deprotection reaction on 7,8-difluoro-3-tertoxy carbonyl amino quinoline; 7,8-difluoroquinoline-3-formic acid is prepared by three steps of carrying out substitution reaction on 7,8-difluoroquinoline, carrying out carbonyl insertion reaction on 3-bromine-7,8-difluoroquinoline and carrying out hydrolysis reaction on 7,8-difluoroquinoline-3-methyl formate. The synthesis method of the intermediate body of 3-amino-7,8-difluoroquinoline is simple in route, high in total yield, convenient to operate, simple in post-treatment, free of poisonous reagent and suitable for large-scale production.
Benzo[f]naphthyridine derivatives, their preparation and compositions containing them
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, (2008/06/13)
Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for preparing such compounds; and compositions comprising them.
