1452572-96-1

Upstream product

• 885952-16-9 2,3-dibromo-6-chloropyridine 
• 536-74-3 phenylacetylene 
• 19798-81-3 2-Amino-6-bromopyridine 
• 89284-11-7 5,6-dibromopyridin-2-ylamine 

Downstream Products

• 1452573-66-8 5-(3,5-dimethyl-1,2-oxazol-4-yl)-6-(2-phenylethynyl)pyridin-2-amine 
• 1452573-08-8 tert-butyl N-[1-[[5-bromo-6-(2-phenylethynyl)pyridin-2-yl]amino]-1-oxo-propan-2-yl]-N-methylcarbamate 
• 1452573-25-9 [6-[2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoylamino]-2-(2-phenylethynyl)pyridin-3-yl]boronic acid 
• 1452572-14-3 N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-6-(2-phenylethynyl)pyridin-2-yl]-2-(trideuteriomethylamino)propanamide 
• 1452573-67-9 tert-butyl N-[1-[[5-(3,5-dimethyl-1,2-oxazol-4-yl)-6-(2-phenylethynyl)pyridin-2-yl]amino]-1-oxopropan-2-yl]-N-(trideuteriomethyl)carbamate 
• 1452571-63-9 N-[5-benzyl-6-(2-phenylethynyl)pyridin-2-yl]-2-(methylamino)-propanamide 
• 1452573-64-6 tert-butyl N-[1-[[5-benzyl-6-(2-phenylethynyl)pyridin-2-yl]amino]-1-oxo-propan-2-yl]-N-methylcarbamate 

Relevant academic research and scientific papers

Synthesis and solid-state fluorescence properties of pentacyclic 7-substituted-indeno[1′,2′:4,5]pyrido[2,1-a]isoindol-5-ones

With the aim to design fluorescent solids, a series of indeno[1′,2′:4,5]pyrido[2,1-a]isoindol-5-ones with various substituents was prepared. In these π-extended pentacyclic derivatives, the presence of a methyl group in the 7-position was found to have a critical influence on the fluorescence properties in the solid state. Crystal packing of the non-substituted derivatives shows strong π-π interactions causing quenching of the fluorescence. In contrast, by introducing a methyl substituent in the 7-position we obtained compounds with fluorescence quantum yield up to 32% in the solid state.

6 - ALKYNYL PYRIDINES AS SMAC MIMETICS

This invention relates to 6-alkynyl-pyridines of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R5 have the meanings given in the claims and in the specification.

5-Alkynyl Pyridine

5-alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R5 have the meanings given in the claims and in the specification.