1452587-93-7Relevant academic research and scientific papers
Copper-catalyzed asymmetric hydrogenation of aryl and heteroaryl ketones
Krabbe, Scott W.,Hatcher, Mark A.,Bowman, Roy K.,Mitchell, Mark B.,McClure, Michael S.,Johnson, Jeffrey S.
, p. 4560 - 4563 (2013)
High throughput screening enabled the development of a Cu-based catalyst system for the asymmetric hydrogenation of prochiral aryl and heteroaryl ketones that operates at H2 pressures as low as 5 bar. A ligand combination of (R,S)-N-Me-3,5-xylyl-BoPhoz and tris(3,5-xylyl)phosphine provided benzylic alcohols in good yields and enantioselectivities. The electronic and steric characteristics of the ancillary triarylphosphine were important in determining both reactivity and selectivity.
