14526-01-3

Usage

Structure

Heterocyclic amine with two pyridine rings and an isoindole ring

Potential applications

Medicinal chemistry and pharmaceutical research, diverse biological activities

Potential therapeutic uses

Anti-cancer agent, other therapeutic uses

Interest to researchers

Drug discovery and development, range of pharmacological properties, treatment of various diseases.

Upstream product

• 504-29-0 2-aminopyridine 
• 119072-55-8 tert-butylisonitrile 
• 7468-67-9 o-formylbenzonitrile 
• 91-15-6 phthalonitrile 

Downstream Products

• 300662-53-7 Cu(II)(1,3-bis(2-pyridylimino)isoindolinate)(O-benzoylsalicylic acid) 
• 300662-52-6 Cu(I)(1,3-bis(2-pyridylimino)isoindoline)(O-benzoylsalicylic acid) 
• 300662-50-4 (Cu(I)(flavonolate)(1,3-bis(2-pyridylimino)isoindoline)) 
• 300662-51-5 (Cu(II)(flavonolate)(1,3-bis(2-pyridylimino)isoindolinate)) 
• 152505-49-2 ({1,3-bis(2-pyridylimino)isoindolinato}(2,3,5,6-tetrachlorophenylcyanamido)nickel(II)) 
• 152505-45-8 ({1,3-bis(2-pyridylimino)isoindolinato}(2-chlorophenylcyanamido)nickel(II)) 
• 1211510-02-9 (1,3-bis(2-pyridylimino)isoindoline(-1H))(4-methoxyphenylethynyl)platinum(II) 
• 1211509-96-4 (1,3-bis(2-pyridylimino)isoindoline(-1H))(phenylethynyl)platinum(II) 
• 1211509-96-4 (1,3-bis(2-pyridylimino)isoindoline(-1H))(phenylethynyl)platinum(II) 
• 1211510-03-0 (1,3-bis(2-pyridylimino)isoindoline(-1H))(4-(trifluoromethyl)phenylethynyl)platinum(II) 
• 1211509-97-5 (1,3-bis(2-pyridylimino)isoindoline(-1H))(4-fluorophenylethynyl)platinum(II) 

Relevant academic research and scientific papers

Metal free direct formation of various substituted pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines and their further functionalization

Original substituted pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines have been prepared following a Groebke-Blackburn-Bienaymé MCR combined with an N-deprotection and a spontaneous final cyclization step in moderate to good yields. The flexibility of the described method enables the introduction of diverse groups in the 6 and 7 positions on the resulting scaffold using commercially available starting materials. Furthermore, a Buchwald-Hartwig cross coupling with a wide range of aryl and hetaryl halides has been successfully reported using our heterocyclic primary amine derivatives.

Lanthanide triiodide-catalyzed amination of phthalonitrile. the structure of 1-isopropylamino-3-(isopropylimino)isoindole

The reactions of phthalonitrile with MeNH2, Pr nNH2, and PriNH2 in the presence of catalytic amounts of LnI3 (Ln = Nd or Dy) or LnI3(THF) 3 (Ln = Gd or Nd) afford 1,3-