1452790-32-7Relevant academic research and scientific papers
Cu(OAc)2 catalyzed ultrasound assisted rapid synthesis of isocoumarin derivatives bearing 3-oxobutyl moiety at C-4 position
Dandela, Rambabu,Moturu, Krishna Murthy VR.,Pal, Manojit,Pothireddy, Mohanreddy,Ramarao, Sidda,Siddaiah, Vidavalur,Venkateshwarlu, Rapolu
, (2022/01/24)
A rapid synthesis of isocoumarins has been achieved via the Cu-catalysed cascade reaction involving tandem intramolecular cyclization followed by olefin addition under ultrasound irradiation. The methodology involved one-pot reaction of 2-alkynylbenzoate
Oxypalladation Initiating the Oxid-ative Heck Reaction with Alkenyl -Alcohols: Synthesis of Isocoumarin–Alkanones
Zheng, Meifang,Huang, Liangbin,Tong, Qizhen,Wu, Wanqing,Jiang, Huanfeng
, p. 663 - 667 (2017/01/18)
Highly regioselective nucleopalladation for the oxidative coupling of internal alkynes with alkenyl alcohols by using green and low-costing oxygen as the sole oxidant was investigated. This one-pot cascade cyclization proceeds through Pd-catalyzed intramolecular C–O bond cyclization, insertion of nonbiased alkenyl alcohols, β-H elimination, and reinsertion of a HPdX species, which is finally transferred to the target ketones. This method has the advantages of mild conditions, good functional group tolerance, and can be performed with unactivated alkenes to afford isocoumarin derivatives.
Palladium(II)-catalyzed tandem annulation reaction of o-alkynylbenzoates with methyl vinyl ketone for the synthesis of isocoumarins
Wang, Huan,Han, Xiuling,Lu, Xiyan
, p. 8626 - 8631 (2013/09/12)
A palladium(II)-catalyzed highly regioselective tandem reactions of o-alkynylbenzoates with methyl vinyl ketone for the synthesis of isocoumarins was developed. It is a convenient, mild and environmentally benign reaction with moderate to high yield. The
