1452791-34-2Relevant academic research and scientific papers
Transition-metal-free catalyzed [3+2] cycloadditions/oxidative aromatization reactions for the synthesis of annulated indolizines
Zhang, Qianwei,Wang, Bin,Ma, Huifang,Ablajan, Keyume
, p. 17000 - 17003 (2019)
In this study, transition-metal-free catalyzed [3+2] cycloadditions/oxidative aromatization three-component reactions for the successful direct construction of pyrrolo[3,4-a]indolizine-1,3(2H)-diones via pyridinium ylides are reported. This method utilize
One-pot synthesis of pyrrolo[3,4-a]indolizine-1,3-diones through [3+2] cycloaddition-oxidation reaction catalyzed by CuII salt and O 2 as the oxidant
Liu, Yun,Hu, Hua-You,Su, Xian-Bin,Sun, Jin-Wei,Cao, Chang-Sheng,Shi, Yan-Hui
, p. 2020 - 2026 (2013/04/24)
An efficient one-pot synthesis of pyrrolo[3,4-a]indolizine-1,3-diones has been developed from maleimides, pyridines, and acyl bromides through a [3+2] cyclization-oxidation reaction catalyzed by CuII salt under O 2 atmosphere. The advantage of this method is the use of molecular oxygen as the oxidant, in the presence of a catalytic amount of hydrated copper(II) chloride, to accomplish the reaction with broad substrate scope and excellent yields. An efficient approach for the synthesis of pyrrolo[3,4-a]indolizine-1,3-diones in excellent yields has been developed. In contrast to previous reports, this work uses molecular oxygen as the oxidant to replace traditional oxidants.
