145280-01-9

Basic information

• Product Name: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>-2-phenylacetate
• Synonyms: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>-2-phenylacetate
• CAS NO: 145280-01-9
• Molecular Weight: 465.633
• Mol File: 145280-01-9.mol

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>-2-phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>-2-phenylacetate(145280-01-9)
• EPA Substance Registry System: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>-2-phenylacetate(145280-01-9)

Safety Data

• Hazardous Substances Data: 145280-01-9(Hazardous Substances Data)

Upstream product

• 65253-04-5 (-)-8-phenylmenthol 
• 2900-27-8 2-(tert-butoxycarbonylamino)-2-phenylacetic acid 
• 117681-86-4 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate 
• 4530-20-5 BOC-glycine 
• 117049-08-8 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl<(tert-butoxycarbonyl)amino>bromoacetate 

Downstream Products

• 2900-27-8 2-(tert-butoxycarbonylamino)-2-phenylacetic acid 
• 102089-74-7 tert-butyl 2-hydroxy-1-phenylethylcarbamate 

Relevant articles and documents

The asymmetric synthesis of α-amino acids via the addition of grignard reagents to imine derivatives

The ester-8-phenylmenthyl N-Boc-glycinate 5a, undergoes free radical bromination by N-bromosuccinimide to give 8-phenylmenthyl N-Boc-bromoglycinate 8. Treatment of the bromide 8 with a variety of Grignard reagents at low temperature gave 8-phenylmenthyl (S-N-Boc-2-alkylgrycinates with high diastereoselectivity. Conditions were found for the hydrolysis of these derivatives with no racemization of the resultant amino acid.

A STEREOSELECTIVE SYNTHESIS OF N-BOC-α-AMINO ALCOHOLS AND α-AMINO ACIDS

A sterteoselective synthesis of N-Boc-α-amino alcohols and α-amino acids via the addition of Grignard reagents to the chiral electrophilic glycine equivalent α-bromo-N-Boc-glycine(-)phenylmenthylester is described.