1452829-00-3 Usage
Uses
SnAP Reagents provide a one-step route, in tandem with various aldehyde substrates, to saturated?N-heterocycles. The synthesis of?N-heterocycles through SnAP Reagents requires mild reaction conditions, and aldehydes bearing aryl, heteroaryl,?glyoxyl,?aliphatic, and halogenated groups are well tolerated. This product was introduced in collaboration with the?Bode Research Group
General Description
SnAP (Sn amino protocol) reagents have been developed by the Bode group. SnAP reagents are air and moisture stable. They can be prepared from simple reactions with cheap raw materials. SnAP 2-Spiro-(4-Pip) M, also referred to as SnAP 2-spiro-(4-piperdine) morpholine, is a regioisomeric SnAP reagent. This reagent can be prepared from N-Boc piperidone.
Check Digit Verification of cas no
The CAS Registry Mumber 1452829-00-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,2,8,2 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1452829-00:
(9*1)+(8*4)+(7*5)+(6*2)+(5*8)+(4*2)+(3*9)+(2*0)+(1*0)=163
163 % 10 = 3
So 1452829-00-3 is a valid CAS Registry Number.
1452829-00-3Relevant articles and documents
SnAP reagents for the transformation of aldehydes into substituted thiomorpholines - An alternative to cross-coupling with saturated heterocycles
Vo, Cam-Van T.,Mikutis, Gediminas,Bode, Jeffrey W.
supporting information, p. 1705 - 1708 (2013/04/10)
It's a SnAP! The transformation of aldehydes into N-unsubstituted 3-thiomorpholines provides a convenient alternative to metal-catalyzed cross-coupling reactions, which are generally unsuited to the functionalization of saturated N-heterocycles. A copper-mediated radical cyclization is the key to the mild conditions, high functional group tolerance, and broad substrate scope offered by these reagents. Copyright
