14529-33-0Relevant academic research and scientific papers
Highly efficient synthesis of chiral α-CF3 amines via Rh-catalyzed asymmetric hydrogenation
Jiang, Jun,Lu, Wenxin,Lv, Hui,Zhang, Xumu
supporting information, p. 1154 - 1156 (2015/03/14)
Highly enantioselective catalytic asymmetric hydrogenation of α-CF3-enamides has been achieved by employing rhodium-DuanPhos as the catalyst, which provides a readily accessible method for the synthesis of chiral trifluoromethylated amines. The reaction has a broad substrate scope; both aryl- and alkyl-substituted α-CF3-enamides worked smoothly and afford the corresponding chiral amines in high yields and excellent enantioselectivities (up to 99% ee).
Trifluoromethylketone sulfides and reversible enzyme inhibition therewith
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, (2008/06/13)
Novel compounds are provided which have the formula STR1 where R is a substituent having at least five multivalent atoms. The compounds are reversible inhibitors of hydrolytic enzymes, and offer potential as drug and pesticide synergists and antagonists. Some are extremely potent inhibitors of juvenile hormone esterases. The compounds having the single 1,1,1-trifluoro-3-substituted thiopropan-2-one moiety can be immobilized to solid supports and used as ligands in affinity chromatography.
