1453-52-7Relevant academic research and scientific papers
ANTIVIRAL OXIME PHOSPHORAMIDE COMPOUNDS
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Page/Page column 28; 29, (2017/07/06)
Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
A process for the preparation of cyclopropyl methylamine
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Paragraph 0021-0022, (2017/03/08)
The invention relates to a method for preparing dicyclopropane methyl amine. The method comprises a step of performing catalytic hydrogenation on the dicyclopropane ketoxime and the hydrogen under the existence of a catalyst to generate the dicyclopropane methyl amine, wherein the raney nickel is taken as a catalyst in the catalytic hydrogenation and the process is performed in the water or the alkaline solution at the temperature of 30-90 DEG C. Compared with the current hydrogenation, the method has the advantages that a high-purity product with obviously increased yield can be obtained, the salt formation and dissociation process in an alcohol solvent can be avoided and the operation can be greatly simplified, besides, the costs of the solvent and the post-processing solvent can be greatly reduced, the wastewater discharge can be reduced and the process is green and environmentally friendly.
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
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Page/Page column 150, (2015/02/02)
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
New imidazoline/α2-adrenoceptors affecting compounds-4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies
Treder, Adam P.,Andruszkiewicz, Ryszard,Zgoda, W?odzimierz,Walkowiak, Aleksandra,Ford, Celeste,Hudson, Alan L.
scheme or table, p. 156 - 167 (2011/03/18)
Compilation of agmatine structure and imidazoline moiety leads to a new group of imidazoline/α2-adrenoceptor ligands, 4(5)-(2-aminoethyl)imidazoline derivatives. In this study the exploration of previously unknown 4(5)-(2-aminoethyl)imidazolines including the analogues of reported imidazoline and α2-aderenoceptors ligands: clonidine, rilmenidine, idazoxan, efaroxan, antazoline, tracizoline is described. The synthesis of a variety of novel 4(5)-(2-aminoethyl)imidazolines and their I 1, I2, α2-adrenoceptors affinities are reported.
