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1453066-47-1

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1453066-47-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1453066-47-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,3,0,6 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1453066-47:
(9*1)+(8*4)+(7*5)+(6*3)+(5*0)+(4*6)+(3*6)+(2*4)+(1*7)=151
151 % 10 = 1
So 1453066-47-1 is a valid CAS Registry Number.

1453066-47-1Downstream Products

1453066-47-1Relevant articles and documents

Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity

Su, Tao,Xie, Shishun,Wei, Hui,Yan, Jun,Huang, Ling,Li, Xingshu

, p. 5830 - 5840 (2013/09/12)

A series of berberine-thiophenyl hybrids were designed, synthesised, and evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and β-amyloid (Aβ) aggregation and as antioxidants. Among these hybrids, compounds 4f and 4i, berberine linked with o-methylthiophenyl and o-chlorothiophenyl by a 2-carbon spacer, were observed to be potent inhibitors of AChE, with IC50 values of 0.077 and 0.042 μM, respectively. Of the tested compounds, 4i was also the most potent inhibitor of BuChE, with an IC50 value of 0.662 μM. Kinetic studies and molecular modelling simulations of the AChE-inhibitor complex indicated that a mixed-competitive binding mode existed for these berberine derivatives. The biological studies also demonstrated that these hybrids displayed interesting activities, including Aβ aggregation inhibition and antioxidant properties.

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