1453070-24-0

Basic information

• Product Name: 3-(difluoromethyl)-5-(trifluoromethyl)benzaldehyde
• Synonyms: 3-(difluoromethyl)-5-(trifluoromethyl)benzaldehyde
• CAS NO: 1453070-24-0
• Molecular Weight: 224.13
• Mol File: 1453070-24-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(difluoromethyl)-5-(trifluoromethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(difluoromethyl)-5-(trifluoromethyl)benzaldehyde(1453070-24-0)
• EPA Substance Registry System: 3-(difluoromethyl)-5-(trifluoromethyl)benzaldehyde(1453070-24-0)

Safety Data

• Hazardous Substances Data: 1453070-24-0(Hazardous Substances Data)

Upstream product

• 32707-89-4 3,5-bis(trifluoromethyl)benzenemethanol 
• 1453070-23-9 1-(difluoromethyl)-3-(trifluoromethyl)-5-vinylbenzene 
• 1214326-55-2 1-bromo-3-(difluoromethyl)-5-(trifluoromethyl)benzene 
• 477535-41-4 3-bromo-5-(trifluoromethyl)benzaldehyde 
• 958258-15-6 3-bromo-5-(trifluoromethyl)benzoyl chloride 
• 880652-44-8 3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide 
• 328-67-6 3-bromo-5-(trifluoromethyl)benzoic acid 

Downstream Products

• 1453070-25-1 C₁₃H₁₄F₅NOS 
• 1453070-26-2 (S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 1453070-27-3 (S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1453070-28-4 (R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)-N-methylethanamine 
• 1453070-29-5 (1S,8aS)-7,7-diallyl-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 
• 1453069-11-8 (1S,8aS)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 

Relevant articles and documents

Selective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes

A selective reductive monodefluorination reaction of trifluoromethyl arenes was developed. Mediated by magnesium metal, various difluoromethylated aromatics were accessed at room temperature in the presence of acetic acid. This protocol shows tolerance to a wide range of functional groups and it was applicable in late-stage hydrodefluorination of complex pharmaceutical compounds, affording the corresponding CF2H analogues and their deuterated (CF2D) counterparts.

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS

The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd