1453083-82-3Relevant academic research and scientific papers
Design, synthesis, and evaluation of novel, selective γ-butyrolactones sigma-2 ligands
Blass, Benjamin E.,Blattner, Kevin M.,Canney, Daniel J.,Gao, Rong,Gordon, John C.,Pippin, Douglas A.
, p. 1713 - 1727 (2021/08/03)
Nearly 40 years after the first disclosure of sigma receptors, the sigma-2 (σ2) receptor was recently identified as the Transmembrane Protein 97 (TMEM97, also known as MAC30 (Meningioma-associated protein). This macromolecule has been associated with a nu
Homologation as a lead modification approach en route to a series of lactone-based muscarinic ligands
Gao, Rong,Bhandare, Richie R.,Canney, Daniel J.
, p. 1023 - 1030 (2014/03/21)
Previous work identified the lactone ring as a useful scaffold for the design of muscarinic ligands and reported a lactone-based ligand with an IC 50 of 340 nM. Using homologation as a lead modification approach, a new series of lactone-based c
