1453095-83-4

Basic information

• Product Name: 3-bromo-6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline
• CAS NO: 1453095-83-4
• Molecular Weight: 350.565
• Mol File: 1453095-83-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-bromo-6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline(1453095-83-4)
• EPA Substance Registry System: 3-bromo-6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline(1453095-83-4)

Safety Data

• Hazardous Substances Data: 1453095-83-4(Hazardous Substances Data)

Upstream product

• 168834-43-3 6-amino-3-chloro-α-cyclopropylethynyl-α-(trifluoromethyl)benzyl alcohol 
• 6746-94-7 Cyclopropylacetylene 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 

Relevant articles and documents

Electrophile-driven copper-catalyzed one-pot synthesis of 3-halogen quinoline derivatives

A convenient and regioselective one-pot synthesis of 3-chloride or 3-bromide quinoline derivatives was achieved through a Grignard addition reaction by alkynyl Grignard regent to o-trifluoroacetyl aniline and a Cu(II)-catalyzed cyclization-halogenation tandem reaction with aqueous HCl or HBr as electrophilic reagent.