1453097-98-7

Upstream product

• 1453098-09-3 2‐isocyano‐1,1':4',1''‐terphenyl 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 76129-23-2 [1,1':4',1''-terphenyl]-2-amine 
• 615-36-1 2-bromoaniline 
• 5122-94-1 4-biphenylboronic acid 
• 1613233-05-8 C₂₀H₁₃ClF₃N 
• 2926-29-6 Langlois reagent 
• 421-83-0 trifluoromethane sulfonyl chloride 

Relevant academic research and scientific papers

An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides

A mild and efficient visible light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides is developed for the synthesis of 6-(trifluoromethyl)phenanthridine derivatives. The reaction involves the generation of radical intermediates from C(sp2)-Cl bonds and a homolytic radical aromatic substitution (HAS) process.

Palladium-catalyzed intramolecular C-H bond functionalization of trifluoroacetimidoyl chloride derivatives: Synthesis of 6-trifluoromethyl- phenanthridines

Highly efficient approaches to obtain 6-trifluoromethyl-phenanthridine derivatives have been realized through the palladium-catalyzed intramolecular C-H bond functionalization of trifluoroacetimidoyl chlorides. The reaction allows the direct formation of

Isocyanide insertion: De novo synthesis of trifluoromethylated phenanthridine derivatives

A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl) phenanthridine derivatives using ionic isocyanide insertion from biphenyl isocyanide derivatives and Umemoto's reagent. These reactions were promoted only by inorganic base in good-to-excellent chemical yields without any external stoichiometric oxidants and radical initiators.

Synthesis of 6-Trifluoromethylphenanthridines through Radical Trifluoromethylation of Isocyanides with Sodium Triflinate under Visible Light

Trifluoromethylation enabled by photochemistry enriched the toolbox of synthetic chemists, to allow the simple and efficient installation of CF3 groups in organic molecules. Herein, we report a cascade addition/annulation reaction of 2-isocyanobiphenyls towards the synthesis of 6-trifluoromethylphenanthridines. It is proposed that this reaction is triggered by the CF3 radical generated from photoexcited 2,3-butanedione (diacetyl) and sodium triflinate. In contrast to classical aromatic trifluoromethylations, this work does not require any additives and features formation of a C–CF3 bond with concomitant construction of an aromatic scaffold.

Light triggered addition/annulation of 2-isocyanobiphenyls toward 6-trifluoromethyl-phenanthridines under photocatalyst-free conditions

A photocatalyst-free, light promoted sequential radical addition/annulation of 2-isocyanobiphenyls to 6-trifluoromethyl phenanthridines is presented. Wide substrate scopes and scale-up experiment demonstrate the promising efficiency and utility of this st

PhI(OAc)2-mediated synthesis of 6-(trifluoromethyl) phenanthridines by oxidative cyclization of 2-isocyanobiphenyls with CF 3SiMe3 under metal-free conditions

A mild and efficient method for the synthesis of 6-(trifluoromethyl) phenanthridines through oxidative cyclization of 2-isocyanobiphenyls with CF3SiMe3 under metal-free conditions was developed. The reaction allows the direct formation of C-CF3 bonds and rapid access to phenanthridine ring systems in one catalytic cycle.