1453110-76-3Relevant academic research and scientific papers
A transition metal-free Minisci reaction: Acylation of isoquinolines, quinolines, and quinoxaline
Siddaraju, Yogesh,Lamani, Manjunath,Prabhu, Kandikere Ramaiah
, p. 3856 - 3865 (2014)
Transition metal-free acylation of isoquinoline, quinoline, and quinoxaline derivatives has been developed employing a cross dehydrogenative coupling (CDC) reaction with aldehydes using substoichiometric amount of TBAB (tetrabutylammonium bromide, 30 mol %) and K2S2O 8 as an oxidant. This intermolecular acylation of electron-deficient heteroarenes provides an easy access and a novel acylation method of heterocyclic compounds. The application of this CDC strategy for acylation strategy has been illustrated in synthesizing isoquinoline-derived natural products.
