36982-71-5Relevant articles and documents
Preparation of N-benzylsulfonamido-1,2-dihydroisoquinolines and their reaction with Raney nickel. A mild, new synthesis of isoquinolines
Larghi, Enrique L.,Kaufman, Teodoro S.
, p. 3159 - 3162 (2007/10/03)
N-benzylsulfonamido-1,2-dihydroisoquinolines react with Raney nickel to provide isoquinotines in excellent yields and under mild, neutral conditions.
Total synthesis of granditropone, grandirubrine, imerubrine, and isoimerubrine
Boger, Dale L.,Takahashi, Kanji
, p. 12452 - 12459 (2007/10/03)
Concise total syntheses of the naturally occurring tropoloisoquinolines grandirubrine (1), imerubrine (2), and isoimerubrine (3) are detailed. The regioselective total synthesis of grandirubrine (1) is based on the [4 + 2]cycloaddition reaction of the α-p
Studies Directed Towards Total Syntheses of the Tropoloisoquinoline Alkaloids Grandirubrine and Imerubrine. I. Preparation of Two 4,5,6-Trimethoxycyclopentisoquinolin-7-ones and Their Response to Robinson Annulation Conditions
Banwell, Martin G.,Bonadio, Anna,Turner, Kathleen A.,Ireland, Neil K.,Mackay, Maureen F.
, p. 325 - 351 (2007/10/02)
In connection with efforts to develop total syntheses of the tropoloisoquinoline alkaloids grandirubrine (1) and imerubrine (2), preparations of tricyclic ketone (8) and the related ethoxycarbonyl system (47) are described.Of the various approaches to (8)
A SIMPLIFIED ISOQUINOLINE SYNTHESIS
Boger, Dale L.,Brotherton, Christine E.,Kelley, Marshall D.
, p. 3977 - 3980 (2007/10/02)
A simple variation of the Pomeranz-Fritsch cyclization provides a short, efficient route to isoquinolines.Treatment of benzylic halides or mesylates 1 with the sodium anion of N-tosyl aminoacetaldehyde dimethyl acetal (2) followed by acid-catalyzed cyclization provides an effective, two-step preparation of isoquinolines 4.
