145313-93-5

Upstream product

• 60159-78-6 8 (H) Dibenzo-8-chinolizinon 
• 917-54-4 methyllithium 
• 145103-18-0 2-[[2-benzoyl-1-cyano-1,2-dihydroisoquinolin-1-yl]methyl]benzoic acid methyl ester 
• 145103-19-1 2-(2-Benzoyl-1-cyan-1,2-dihydro-1-isochinolylmethyl)-benzoesaeureethylester 
• 87-24-1 ethyl 2-methylbenzoate 
• 150982-69-7 2-(2-bromomethyl-phenyl)-2-methyl-[1,3]dioxolane 
• 150982-68-6 2-methyl-2-(2-methylphenyl)-1,3-dioxolane 
• 844-25-7 2-benzoyl-1-cyano-1,2-dihydroisoquinoline 
• 150982-74-4 1-<2-(2-Methyl-1,3-dioxolan-2-yl)benzyl>-isochinolin 
• 150982-72-2 2-Benzoyl-1-<2-(2-methyl-1,3-dioxolan-2-yl)benzyl>-1-cyan-1,2-dihydroisochinolin 
• 577-16-2 2-Methylacetophenone 

Relevant academic research and scientific papers

Protoberberines from Reissert compounds, II: A new synthesis of 8-methyldibenzo[a,g]quinolizidines

The Reissert compounds 16 are benzylated by 2-bromomethylacetophenone dioxolane 14 to give the dihydroisoquinolines 5. Treatment of 5 with KOH yields the 1-benzylisoquinolines 6 which spontaneously form the deoxygenated coralynes 4 in acidic solution. 4a

Synthesis of Dibenzoquinolizines - A New Entry to Protoberberines

A novel synthesis to prepare dibenzo-8-quinolizinones 8 is reported using the intramolecular cyclisation of the benzylated Reissert compounds 6 for the key step.Methylation of 8 by methyllithium gives partial deoxygenated coralynes 10 which in turn can be reduced by NaBH4 yielding the 8-methyltetrahydro-protoberberines 11.The structures are assigned by NMR-spectroscopy. Keywords.Reissert compounds; Intramolecular cyclisation; Dibenzo-8-quinolizinones; Deoxygenated coralynes; 8-Methyltetrahydro-protoberberines.