1453217-95-2Relevant academic research and scientific papers
TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
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, (2013/11/05)
The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. More particularly, the tricyclic nucleosides provided herein comprise a tricyclic ribosyl sugar moiety having a bridge between the 4' and 2' ring carbon ato
A constrained tricyclic nucleic acid analogue of α-l-LNA: Investigating the effects of dual conformational restriction on duplex thermal stability
Hanessian, Stephen,Wagger, Jernej,Merner, Bradley L.,Giacometti, Robert D.,stergaard, Michael E.,Swayze, Eric E.,Seth, Punit P.
, p. 9064 - 9075 (2013/10/08)
A constrained tricyclic analogue of α-l-LNA (2), which contains dual modes of conformational restriction about the ribose sugar moiety, has been synthesized and characterized by X-ray crystallography. Thermal denaturation experiments of oligonucleotide se
