956485-08-8

Upstream product

• 956485-07-7 ((3aR,6S,6aR)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[3,2-d][1,3]dioxole-5,5-diyl)dimethanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 2595-05-3 Diacetone D-glucose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 956485-06-6 3-O-(2-naphthylmethyl)-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 1091607-89-4 (R)-1-((3aR,5R,6R,6aR)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[3,2-d][1,3]dioxol-5-yl)ethane-1,2-diol 
• 1070968-94-3 C₂₀H₂₄O₆ 
• 1057385-93-9 (3aR,5S,6R,6aR)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[3,2-d][1,3]dioxole-5-carbaldehyde 
• 620630-82-2 1,2 5,6-O-di(isopropylidene)-α-D-allofuranose 
• 939-26-4 2-bromomethylnaphthyl bromide 

Downstream Products

• 1093849-11-6 C₃₇H₄₂O₆Si 
• 1160288-70-9 5-O-(tert-butyldiphenylsilyl)-4-C-((R)-1-hydroxyethyl)-1,2-O-isopropylidene-3-O-(2-naphthylmethyl)-α-D-ribofuranose 
• 1174917-65-7 C₃₈H₄₆O₈SSi 
• 1197032-94-2 (1S,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-6-methyl-7-(2-naphthylmethyloxy)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 1197032-95-3 (1R,3R,4R,6S,7S)-1-(tert-butyldiphenylsilyloxymethyl)-7-hydroxy-6-methyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 1174917-95-3 C₃₈H₄₆O₈SSi 
• 1174917-96-4 1,2-di-O-acetyl-5-O-(tert-butyldiphenylsilyl)-4-C-((1S)-1-methanesulfonyloxyethyl)-3-O-(2-naphthylmethyl)-D-ribofuranose 
• 1352230-45-5 C₃₉H₄₄N₂O₇Si 
• 1352230-26-2 C₄₀H₄₆N₂O₉SSi 
• 1352230-33-1 C₄₁H₄₅F₃N₂O₁₁S₂Si 
• 1352231-54-9 C₃₄H₃₇N₃O₇ 
• 1352229-98-1 C₄₀H₄₆N₂O₉SSi 
• 1352230-05-7 C₄₁H₄₅F₃N₂O₁₁S₂Si 

Relevant academic research and scientific papers

BICYCLIC MORPHOLINO COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

The present invention provides bicyclic morpholino compounds and oligomeric compounds prepared therefrom. More particularly, incorporation of one or more of the bicyclic morpholino compounds into an oligomeric compound is expected to enhance one or more p

Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom

Provided herein are novel bicyclic nucleosides, oligomeric compounds that include such bicyclic nucleosides and methods of using the oligomeric compounds. More particularly, the novel bicyclic nucleosides comprise a furanose ring system having a bridge co

PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS

Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

TRICYCLIC NUCLEIC ACID ANALOGS

The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.

TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. More particularly, the tricyclic nucleosides provided herein comprise a tricyclic ribosyl sugar moiety having a bridge between the 4' and 2' ring carbon ato

BASE MODIFIED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

Provided herein are novel base modified bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, novel pyrimidine bicyclic nucleosides are provided wherein each pyrimidine base is subs

Carbocyclic bicyclic nucleic acid analogs

Provided herein are saturated and unsaturated carbocyclic bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using these oligomeric compounds. The saturated and unsaturated carbocyclic bicyclic nucleosides are useful for enhancin

SUBSTITUTED 2 '-AMINO AND 2 '-THIO-BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

Provided herein are 2'-amino and 2'-thio bicyclic nucleosides and oligomenc compounds prepared therefrom. The novel bicyclic nucleosides provided herein are expected to be useful for enhancing one or more properties of the oligomeric compounds they are in

5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

Provided herein are novel 5'-(S)-CH3 substituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the furanose ring of each of the novel 5'-(S)-CH3 substi

Synthesis and biophysical evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl nucleic acid analogues

"Chemical Equation Presented" We have recently shown that combining the structural elements of 2′O-methoxyethyl (MOE) and locked nucleic acid (LNA) nucleosides yielded a series of nucleoside modifications (cMOE, 2′,4′-constrained MOE; cEt, 2′,4′-constrain