145324-18-1Relevant articles and documents
Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate across Activated Alkenes
Alektiar, Sara N.,Wickens, Zachary K.
, p. 13022 - 13028 (2021/09/03)
Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across diverse functionalized alkene substrates with excellent regioselectivity. This operationally simple procedure can be readily scaled in batch at low photocatalyst loading (0.01% photocatalyst). Furthermore, this new reaction can leverage commercially available formate carbon isotologues to enable the direct synthesis of isotopically labeled carboxylic acids. Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2?- as a key reactive intermediate.
Novel convenient synthesis of mitiglinide
Huang, Wei,Cen, Jun-Da
, p. 2153 - 2157 (2008/02/07)
A novel convenient synthesis of the hypoglycemic agent mitiglinide was developed. (2S)-4-[(3aR,7aS)-Octahydro-2H-isoindol-2-yl]-4-oxo-2-benzyl-butanoic acid (6) was prepared by selective hydrolysis of ethyl 4-[(3aR,7aS)-octahydro- 2H-isoindol-2-yl]-4-oxo-
Preparation of optically active succinic acid derivatives: I. Optical resolution of 2-benzyl-3-(cis-hexahydroisoindolin-2-ylcarbonyl)-propionic acid
Yamaguchi, Toshiaki,Yanagi, Takashi,Hokari, Hiroshi,Mukaiyama, Yuko,Kamijo, Tetsuhide,Yamamoto, Iwao
, p. 1518 - 1520 (2007/10/03)
(+)-Monocalcium bis[(2S)-2-benzyl-3-(cis-hexahydroisoindolin-2- ylcarbonyl)propionate] dihydrate (KAD-1229, 1) is an optically active succinic acid calcium salt derivative with potent hypoglycemic effect. We investigated two optical resolution method. 2-B
