145375-43-5

Basic information

• Product Name: [2(S)-cis]-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid
• Synonyms: MITIGLINIDE;Mitiglinide [inn];Unii-D86I0xlb13;(2S)-4-[(3aR,7aS)-octahydro-1H-isoindol-2-yl]-2-benzyl-4-oxobutanoic acid;[2(s)-cis]-octahydro-gamma-oxo-alpha-(phenylmethyl)-2h-isoindole-2-butanoic acid
• CAS NO: 145375-43-5
• Molecular Formula: C₁₉H₂₅NO₃
• Molecular Weight: 315.41
• EINECS: 1312995-182-4
• Mol File: 145375-43-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 519.6 °C at 760 mmHg
• Flash Point: 268 °C
• Appearance: /
• Density: 1.175
• Vapor Pressure: 1.27E-11mmHg at 25°C
• Refractive Index: 1.567
• PKA: 4.37±0.10(Predicted)
• CAS DataBase Reference: [2(S)-cis]-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2(S)-cis]-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid(145375-43-5)
• EPA Substance Registry System: [2(S)-cis]-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid(145375-43-5)

Safety Data

• Hazardous Substances Data: 145375-43-5(Hazardous Substances Data)

Usage

Uses

Antineoplastic.

InChI:InChI=1/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)

Upstream product

• 1141896-00-5 (2S)-2-benzyl-1-((4R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-(cis-hexahydro-isoindolin-2-yl)-butane-1,4-dione 
• 1470-99-1 cis-hexahydroisoindoline 
• 865538-96-1 (S)-3-benzyldihydrofuran-2,5-dione 
• 3972-36-9 (2S)-benzylsuccinic acid 
• 1220913-25-6 (S)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid 
• 161829-92-1 (3aR,7aS)-octahydro-1H-isoindole hydrochloride 
• 2144-87-8 (cis)-2,3,3a,4,7,7a-hexahydro-1H-isoindole 
• 5653-88-3 2-benzylidenesuccinic acid 
• 100-52-7 benzaldehyde 
• 125702-11-6 (E)-benzylidenesuccinic anhydride 
• 145323-82-6 4-(3aR,7aS)-Octahydro-isoindol-2-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyric acid 
• 140903-48-6 phenylmethyl 3-carboxy-2(S)-(phenylmethyl)-1-propanoate 
• 204187-32-6 (S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl) ester 
• 157060-06-5 (S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester 

Relevant articles and documents

A kind of improved mitiglinide preparation method (by machine translation)

The invention relates to an improved mitiglinide preparation method, the method comprises the steps of (1): preparation of acyl chloride; step (2): active preparation of amides; step (3): 2 - (S)- benzyl - 4 - oxo - (cis - full hydrogenation isoindol - 2 - yl) butyric acid preparation; step (4): mitiglinide preparation, the process of the method is simple, high yield, low production cost, compared with the prior-anhydride method process, the purity of the product is obviously improved, easy to industrial production. (by machine translation)

A kind of improved mitiglinide industrial preparation method

The invention provides an improved mitiglinide calcium (I) preparation method, and is characterized in that the preparation method successively comprises the steps: step 1, preparation of 2-benzyl succinic acid; step 2, preparation of (S)-2-benzyl succinic acid; step 3, preparation of 2-(S)-benzyl-4-oxo-(cis-perhydroisoindole-2-yl)butyric acid; and step 4, preparation of mitiglinide calcium. The invention provides the mitiglinide calcium industrialized preparation method having the advantages of being economical and practical, simple to operate, short in reaction period and high in yield.

Mitiglinide calcium method for the preparation of

The invention provides a novel preparation method for Mitiglinide calcium hydrate. The method comprises the following steps: adopting cis-hexahydroisoindole as a raw material, conducting acylation reaction, hydrocarbonylation reaction, hydrolysis reaction