145325-40-2

Usage

Uses

Used in Pharmaceutical Development:
4-Bromothieno[2,3-c]pyridine-2-carboxylic acid methyl ester is used as a starting material for the synthesis of pharmaceuticals due to its potential therapeutic properties and ability to be modified for specific medicinal applications.
Used in Organic Chemistry Research:
In the field of organic chemistry, 4-Bromothieno[2,3-c]pyridine-2-carboxylic acid methyl ester serves as a valuable compound for research purposes, enabling the exploration of new chemical reactions and the development of novel synthetic pathways.

InChI:InChI=1/C9H6BrNO2S/c1-13-9(12)7-2-5-6(10)3-11-4-8(5)14-7/h2-4H,1H3

Upstream product

• 2365-48-2 Methyl thioglycolate 
• 625-92-3 3,5-dibromopyridine 
• 70201-42-2 3,5-dibromopyridine-4-carboxaldehyde 

Downstream Products

• 870243-58-6 methyl thieno[2,3-c]pyridine-2-carboxylate 
• 478149-00-7 thieno[2,3-c]pyridine-2-carboxylic acid 
• 1296224-08-2 4-bromothieno[2,3-c]pyridine 
• 1151512-25-2 4-bromothieno[2,3-c]pyridine-2-carboxylic acid 
• 870238-39-4 4-bromo-7-chloro-thieno[2,3-c]pyridine-2-carboxylic acid methyl ester 
• 1153577-15-1 C₂₁H₁₅NO₂S 
• 870243-94-0 (4-bromo-thieno[2,3-c]pyridin-2-yl)-methanol 

Relevant academic research and scientific papers

Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors

Bicyclic heteroaromatic motifs with hydrogen bond donor–acceptor hinge binder motifs are frequently used as ATP-mimetic kinase inhibitors. Althought the thieno[2,3-c]pyridine scaffold also meets these criteria its use was limited so far by the availability of synthetic building blocks. Inspired by two X-ray structures of kinase bound thieno[2,3-c]pyridines we prepared a diverse collection of simple thieno[2,3-c]pyridine derivatives that could serve as starting points for future drug discovery programs. In our search for inhibitors of the GRK2 kinase we also identified a hit compound bearing the thieno[2,3-c]pyridine moiety. Following a structure-driven optimization process a collection of potent and highly ligand efficient inhibitors were prepared and characterized, which could form the basis of a future drug discovery program. Graphical abstract: [Figure not available: see fulltext.]

Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof

The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.

AMPK INHIBITORS

The 5'-AMP-activated protein kinase AMPK functions as a master switch to maintain cellular and whole-body energy homeostasis and abnormal activity profiles of AMPK may cause pathological disorders. The present invention relates to a series of compounds (I

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.

AMIDO-BENZYL SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment of an NAMPT-mediated disease or condition in a subject, selected from solid or liquid tumor, rheumat

ALKYL-AND DI-SUBSTITUTED AMIDO-BENZYL SULFONAMIDE DERIVATIVES

The present invention relates to certain alkyl- and di-substituted amido-benzyl sulfonamide compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment of NAMPT-mediated disorders, such as diabetes, rheumatoid arthritis,

A facile and general synthesis of 2,4-di- and 2,4,7-trisubstituted thieno[2,3-c]pyridines

(Chemical Equation Presented) Treatment of 3,5-dibromo- or 3,5-dichloro-pyridine-4-carboxaldehyde 2 with one equivalent of methyl thioglycolate, followed by exposure to base, provided 4-bromo- or 4-chloro-thieno[2,3-c]pyridine-2-carboxylate 4 in good yiel