1153577-15-1Relevant articles and documents
Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-α production
Cusack, Kevin,Allen, Hamish,Bischoff, Agnieszka,Clabbers, Anca,Dixon, Richard,Fix-Stenzel, Shannon,Friedman, Michael,Gaumont, Yvette,George, Dawn,Gordon, Thomas,Grongsaard, Pintipa,Janssen, Bernd,Jia, Yong,Moskey, Maria,Quinn, Christopher,Salmeron, Andres,Thomas, Christine,Wallace, Grier,Wishart, Neil,Yu, Zhengtian
scheme or table, p. 1722 - 1725 (2010/01/16)
COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-α and other pro-inflammatory cytokines such as IL-1β via the ERK/MAP kinase pathway. As TNF-α and IL-1β are clinically validated targets for therapeutic intervention in