1453299-99-4Relevant academic research and scientific papers
A new route to the synthesis of isoxazoline derivatives from dihydropyran via cycloaddition reaction in ionic liquid
Chakraborty, Bhaskar,Sharma, Chiran Devi
, p. 5532 - 5536 (2013/09/23)
A new approach to the synthesis and 1,3-dipolar cycloadditions of nitrones has been described from 2,3-dihydro-4H-pyran and various hydroxylamines, with electron-deficient alkynes for the synthesis of isoxazoline derivatives. Significant rate acceleration and improved yields of exclusively exo isoxazolines in 1-butyl-3-methylimidazolium based ionic liquids have been observed. Novel isoxazolines may be used as a precursor for the synthesis of variety of peptides.
