3505-87-1

Usage

Uses

Used in Pharmaceutical Industry:
Phenol, 4-(hydroxyamino)is used as a key intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties. It plays a crucial role in the production of drugs with diverse therapeutic applications, including analgesics, antipyretics, and anti-inflammatory agents.
Used in Agrochemical Industry:
In the agrochemical sector, Phenol, 4-(hydroxyamino)serves as a building block for the development of agrochemicals, such as herbicides, pesticides, and plant growth regulators. Its reactivity and functional groups enable the creation of compounds that can effectively target and control pests and diseases in agriculture.
Used in Organic Synthesis:
Phenol, 4-(hydroxyamino)is utilized as a versatile starting material in organic synthesis, allowing the formation of a wide range of organic compounds. Its ability to undergo various chemical reactions, such as oxidation, reduction, and substitution, makes it a valuable component in the synthesis of dyes, pigments, and other specialty chemicals.
Used in Skincare and Cosmetic Products:
Leveraging its antioxidant and anti-inflammatory properties, Phenol, 4-(hydroxyamino)is incorporated into skincare and cosmetic formulations to provide beneficial effects on the skin. It can help protect the skin from oxidative stress, reduce inflammation, and improve overall skin health.
Used in Material Science:
In the field of material science, Phenol, 4-(hydroxyamino)has potential applications in the development of polymers and advanced materials. Its functional groups and reactivity enable the creation of novel materials with unique properties, such as enhanced stability, improved mechanical strength, and tailored chemical functionalities.

Upstream product

• 100-02-7 4-nitro-phenol 

Downstream Products

• 54337-57-4 4-isonitramino-phenol; ammonium salt 
• 1453299-96-1 C₁₁H₁₅NO₃ 
• 1453299-99-4 C₁₇H₂₁NO₇ 
• 1453300-02-1 C₁₅H₁₇NO₇ 
• 123-30-8 4-amino-phenol 

Relevant academic research and scientific papers

Synthesis and microbiological activities of novel acyclic nitrones

In this article, the synthesis, antibacterial and antifungal activities of α-(5-(R)-2-thiophyl)-N-(4-R′) phenyl nitrones are reported. The synthesis was achieved by the condensation of N-substituted hydroxylamine [4-R′-phenylhydroxylamine] with 5-R-2-thiophenecarboxaldehyde in boiling absolute ethanol. The chemical structure of this nitrones was identified by spectroscopic techniques (IR and NMR). The antibacterial and antifungal activities were evaluated against bacteria: B. substilis, S. aureus, E. coli, S. enterica and fungus: M. ramannianus and F. oxysporium f.sp. albedinis. The reactivity of this reaction was making clear according the director condition.

Ultrasonic-assisted preparation and characterization of magnetic ZnFe2O4/g-C3N4 nanomaterial and their applications towards electrocatalytic reduction of 4-nitrophenol

Nanoball-structured ferromagnetic zinc ferrite nanocrystals (ZnFe2O4 NPs) entrapped with graphitic-carbon nitride (g-C3N4) was produced via straightforward and facile sonochemical synthetical technique (titanium

Highly biocompatible jujube polysaccharide-stabilized palladium nanoparticles with excellent catalytic performance

The development of stable and biocompatible palladium nanoparticles (Pd NPs) catalysts has been drawing great interest. In this study, Pd NPs were prepared through a green method, where jujube polysaccharide (JP) was employed as both reducing and stabilizing agents for the first time. The JP stabilized palladium nanoparticles (Pdn-JP NPs) displayed small size, high stability, good biocompatibility and excellent catalytic efficiency. Pd50-JP NPs showed high stability up to two weeks in solutions of a wide pH range (4-9). Pd50-JP NPs showed negligible cytotoxicity against HeLa cells at a high concentration of up to 400 μg mL-1. Furthermore, Pdn-JP NPs showed excellent catalytic activity for reduction of 4-nitrophenol (4-NP) in the presence of sodium borohydride (NaBH4). The normalized rate constant (knor) and turnover frequency (TOF) of Pd50-JP NPs were as high as 38.4 s-1 mM-1 and 4455 h-1, respectively. The prepared Pdn-JP NPs will have various potential applications in bio-related catalysis in the future.

Decorating of ultra small and recyclable nanoscale zero-valent iron on NH2-SiO2 for enhanced high-performance removal of water pollutants

The synthesis of nanoscale zero-valent iron (NZVI) with dimensions ranging from 20 to 100 nm has received tremendous attention in the control of environmental pollutants. However, due to strong magnetic attraction and van der Waals forces of NZVI, creating well-dispersed and stable NZVI particles with subnanometre size while avoiding their aggregation and retaining surface activity is a challenge. Here, for the first time, a novel Fe0@NH2-SiO2 nanocomposite was prepared by making SiO2 amino-functionalization in a simple process of hydrolysis polymerization, grafting Fe3+ on NH2-SiO2 nanospheres, and reduction by sodium borohydrid. It was found that the surface of NH2-SiO2 nanospheres (around 200 nm) was uniformly decorated by plentiful of well-defined Fe0 nanoparticles with a diameter of 0 nanoparticles showed a remarkable reduction activity in the application for the removal of water pollutants, and could be recycled easily with the aid of NaBH4.

Rhodium(III)-catalyzed internal oxidative coupling of N-hydroxyanilides with alkenes via C-H activation

Abstract Described herein is an efficient new method for ortho-olefination of anilides in the presence of AgSbF6 and NaOAc via rhodium(III)-catalyzed internal oxidative C-H bond activation based on hydroxyl as directing and oxidative group. A range of alkenes and functional groups on acetanilides is supported and a possible mechanism is proposed according to the experimental results.

Investigations on the Kinetics and Mechanism of Polarigraphic Reduction of o-, m- and p-Nitrotoluenes and o-, m- and p-Nitrophenols in the presence of Ionic and non-Ionic Surfactants

Polarographic behaviour of o-, m- and p-nitrotoluenes (4percent, V/V, ethanolic solution) in the presence of ionic and non-ionic surfactants at their concentrations just sufficient to suppress the maxima has been studied as a function of pH of Britton-Robinson (BR) buffer.The present study aims at investigating the kinetics and mechanism of the reduction of these compounds at the d.m.e. which has been found to be diffusion-controlled and irreversible.The potential-dependent rate constant, kf,h has been calculated by Koutecky's method at different pH values of BR buffer and the values of kinetic parameters (αna and kf,h0) have been calculated from log kf,h Vs Ed.e. plots which are linear thereby suggesting that only a single rate-determining step is involved in the reduction of each depolarizer.Based on the values of kinetic parameter, αna and the variation of E1/2 with pH, the stoichiometry of the rate-determinig step, in each case, has been established thereby leading to the postulation of a mechanism for the polarographic reduction of each depolarizer.

Kinetics and Mechanism of Polarographic Reduction of Aromatic Nitro Compounds in Aqueous Alcoholic Medium

Polarographic reduction of nitrobenzene, ortho-, meta- and para- chloronitrobenzenes, nitrotoluenes, nitrophenols and nitrobenzaldehydes has been studied in 25percent (v/v) aqueous ethanolic solutions, using Britton-Robinson (BR) buffer of varying pH values.KCl (0.1 M) has been used as the supporting electrolyte and Triton X-100 (0.001percent) as the maxima suppressor.The potential-dependent rate constant, kf,h has been calculated by Koutecky's method at different pH values and the values of kinetic parameters (αna and kf,h) have been calculated from logkf,h versus Ed.e. plots which are linear thereby suggesting that only a single rate-determining step is involved in the electrode process of each depolarizer.Based on the values of kinetic parameter, αna and the variation of E1/2 with pH, the stoichiometry of the rate-determining step has been established.This has led to the postulation of a tentative mechanism for the polarographic reduction of each depolarizer.Besides, the effect of the nature and position of various substituents, viz.Cl, CH3, OH and CHO on the kinetics of the polarographic reduction of NO2 group has been investigated.