14533-80-3Relevant academic research and scientific papers
Hydrogen-bonding and C-H...π interactions in ethyl 4-acetyl-5-methyl-3-phenyl-1H-pyrrole-2-carboxylate monohydrate
Silva, Manuela Ramos,Beja, Ana Matos,Paixo, Jose Antonio,Sobral, Abilio J.F.N.,Lopes, Susana H.,Rocha Gonsalves
, p. o685-o687 (2002)
The hydrogen-bonding and C-H···π interactions in ethyl 4-acetyl-5-methyl-3-phenyl-1H-pyrrole-2-carboxylate monohydrate were studied. In the above compound three strong hydrogen bonds link substituted pyrrole and water molecules to form infinite chains in
Pyrrole BET inhibitor and preparation method and application thereof
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Paragraph 0203; 0205-0207, (2021/08/19)
The invention discloses a pyrrole BET inhibitor and a preparation method and application thereof. The compound is a structure as shown in a general formula (I) or one or a mixture of more of a tautomer, a meso-mer, a raceme, an enantiomer and a diastereoisomer of the compound, or a pharmaceutically acceptable salt of the compound. According to the compound or the mixture thereof or the pharmaceutically acceptable salt thereof, ethyl acetoacetate derivatives and amino aryl ethyl ketone serve as starting raw materials, the compound of the general formula (I) is obtained through a continuous reaction, the preparation method is simple and convenient, the raw materials are easy to obtain, and the preparation method has good applicability, and the medicine taking the derivative as an active ingredient can be used in medicines for effectively preventing and/or treating BET protein related diseases.
Pyrrole derivative as well as preparation method and application thereof
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Paragraph 0081; 0086; 0100-0104, (2020/09/12)
The invention belongs to the field of medical chemistry, and relates to a pyrrole derivativex as well as a preparation method and application thereof. A compound with a structure shown as a general formula (I), or one or a mixture of more of a tautomer, a
Domino transformation of isoxazoles to 2,4-dicarbonylpyrroles under Fe/Ni relay catalysis
Galenko, Ekaterina E.,Galenko, Alexey V.,Khlebnikov, Alexander F.,Novikov, Mikhail S.
, p. 18172 - 18176 (2015/05/12)
The domino reaction of 5-alkoxy- or 5-aminoisoxazoles, under metal relay catalysis, with symmetric 1,3-diketones gives 4-acylpyrrole-2-carboxylic acid derivatives in high yield. Esters and amides of acylacetic acids react regioselectively, giving derivati
