1453382-98-3Relevant academic research and scientific papers
An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines
Guo, Ran-Ning,Cai, Xian-Feng,Shi, Lei,Ye, Zhi-Shi,Chen, Mu-Wang,Zhou, Yong-Gui
, p. 8537 - 8539 (2013/09/23)
An efficient iridium-catalyzed asymmetric hydrogenation of the fluorinated isoquinoline derivatives has been successfully developed for the synthesis of chiral fluorinated tetrahydroisoquinoline derivatives with up to 93% ee. This methodology features the use of a hydrochloride salt as well as a catalytic amount of halogenated hydantoin which were vital for the reactivity, enantioselectivity, and inhibition of the hydrodefluorination pathway. The Royal Society of Chemistry 2013.
