1453422-08-6Relevant academic research and scientific papers
Structural Modifications of Benzimidazoles via Multi-Step Synthesis and Their Impact on Sirtuin-Inhibitory Activity
Yoon, Yeong Keng,Choon, Tan Soo
, p. 1 - 8 (2016/01/29)
Benzimidazole derivatives have been shown to possess sirtuin-inhibitory activity. In the continuous search for potent sirtuin inhibitors, systematic changes on the terminal benzene ring were performed on previously identified benzimidazole-based sirtuin i
Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties
Yoon, Yeong Keng,Ali, Mohamed Ashraf,Wei, Ang Chee,Shirazi, Amir Nasrolahi,Parang, Keykavous,Choon, Tan Soo
, p. 448 - 454 (2014/07/21)
Two series of novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity. Among the newly synthesized compounds, compound 4j displayed the best inhibitory activity for SIRT1 (IC50 = 54
