179942-75-7Relevant academic research and scientific papers
Synthesis and evaluation of iodinated benzamide derivatives as selective and reversible monoamine oxidase B inhibitors
Ohmomo,Murakami,Hirata,Sugimoto,Magata,Miyahara,Tanaka,Yokoyama
, p. 1789 - 1792 (1992)
A new series of iodinated analogues of N-(2-aminoethyl)benzamide was synthesized and evaluated for inhibitory potency and specificity toward monoamine oxidase type-B (MAO-B). Among them, N-(2-aminoethyl)-2-chloro-4-iodobenzamide hydrochloride (2d) showed high inhibitory potency and selectivity against MAO-B. The type of MAO-B inhihition by 2d was non-competitive and the inhibition constant (K(i)) was 0.80 μM. Strong and selective in vivo MAO-B inhibition by 2d was also confirmed. The brain MAO-B inhibition by 2d was reversible and the enzyme activity completely returned to the control value 24 h after administration. Compound 2d was, therefore, considered to be a candidate for advanced development as a radioiodinated ligand that may be useful for functional MAO-B studies in the living brain using single photon emission computer tomography.
PYRIDINE COMPOUNDS AND USES THEREOF
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Page/Page column 25; 26, (2013/03/26)
The present invention is directed to pyridine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psych
Substituted benzyl pyrimidines
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, (2008/06/13)
Compounds of the formula: STR1 in which R1 is lower alkoxy, R2 is bromine or lower alkoxy, and R3 is aryl, heteroaryl or a group --Q--R30, wherein Q is ethylene, vinylene or ethynylene and R30 is aryl, heteroaryl, lower alkoxycarbonyl or carbamoyl; hydrolyzable esters of carboxylic acids of formula I; and pharmaceutically acceptable salts of these compounds are useful for treating infectious diseases.
