1453477-76-3Relevant academic research and scientific papers
An Efficient Microwave-Assisted Propylphosphonic Anhydride (T3P )-Mediated One-Pot Chromone Synthesis via Enaminones
Balakrishna,Kandula, Venu,Gudipati, Ramakrishna,Yennam, Satyanarayana,Devi, P. Uma,Behera, Manoranjan
supporting information, p. 1087 - 1091 (2018/04/30)
An efficient synthesis of 4 H -chromene-4-ones via enamino ketones, with cyclization by using T3P under microwave heating is described. This is the first report for the synthesis of chromones by using T3P . Significant features of this method include short reaction times and high-purity products.
A Concise Synthesis of Pyrazole Analogues of CombretastatinA1 as Potent Anti-Tubulin Agents
Zaninetti, Roberta,Cortese, Salvatore V.,Aprile, Silvio,Massarotti, Alberto,Canonico, Pier Luigi,Sorba, Giovanni,Grosa, Giorgio,Genazzani, Armando A.,Pirali, Tracey
, p. 633 - 643 (2013/08/22)
CombretastatinA1 (CA1) binds to the β-subunit at the colchicine binding site of tubulin and inhibits polymerization. As such, it is both an antitumor agent and a vascular disrupting agent. It has been shown to be at least tenfold more potent than combreta
