53948-03-1Relevant academic research and scientific papers
A Concise Synthesis of Pyrazole Analogues of CombretastatinA1 as Potent Anti-Tubulin Agents
Zaninetti, Roberta,Cortese, Salvatore V.,Aprile, Silvio,Massarotti, Alberto,Canonico, Pier Luigi,Sorba, Giovanni,Grosa, Giorgio,Genazzani, Armando A.,Pirali, Tracey
, p. 633 - 643 (2013/08/22)
CombretastatinA1 (CA1) binds to the β-subunit at the colchicine binding site of tubulin and inhibits polymerization. As such, it is both an antitumor agent and a vascular disrupting agent. It has been shown to be at least tenfold more potent than combreta
