1453491-75-2Relevant academic research and scientific papers
Palladium-Catalyzed Base-Promoted Arylation of Unactivated C(sp3)–H Bonds by Aryl Iodides: A Practical Approach To Synthesize β-Aryl Carboxylic Acid Derivatives
Gou, Quan,Liu, Gang,Zhou, Lanxiu,Chen, Suiyun,Qin, Jun
, p. 6314 - 6318 (2017)
A highly efficient protocol for the β-arylation of carboxylic amides by aryl iodides under PdCl2(CH3CN)2/CsOAc catalysis was developed. This method was found to tolerate a broad scope of substrates and was successfully employed in the preparation of a variety of β-aryl α-amino and γ-amino acid derivatives. The utility of this method was further illustrated in the synthesis of the psychotropic drug (±)-phenibut and β-aryl bile acid analogues.
Palladium-catalyzed Cs2CO3-promoted arylation of unactivated C(sp3)-H bonds by (diacetoxyiodo)arenes: Shifting the reactivity of (diacetoxyiodo)arenes from acetoxylation to arylation
Gou, Quan,Zhang, Zhao-Fu,Liu, Zhi-Cheng,Qin, Jun
, p. 3176 - 3186 (2015/03/30)
PdCl2(CH3CN)2-catalyzed arylation of unactivated C(sp3)-H bonds using (diacetoxyiodo)arenes as arylation reagents is reported. The reactivity of (diacetoxyiodo)arenes as arylation reagents is enabled in the presence of Cs2CO3 under the reaction conditions. This arylation method is highly efficient and occurs without the use of silver salt. The reaction tolerates a broad substrate scope that was not demonstrated by other silver salt-free C(sp3)-H bond arylation conditions. The synthetic utility of the method is further illustrated in the synthesis of the psychotropic drug phenibut. A detailed mechanism study has been conducted to understand the reaction pathway.
Direct arylation of primary and secondary sp3 C-H bonds with diarylhyperiodonium salts via Pd catalysis
Pan, Fei,Shen, Peng-Xiang,Zhang, Li-Sheng,Wang, Xin,Shi, Zhang-Jie
supporting information, p. 4758 - 4761 (2013/10/08)
Palladium-catalyzed primary and secondary sp3 C-H bond arylation is reported. The method using diarylhyperiodonium salts as arylation reagents shows good functional group tolerance and proceeds under mild reaction conditions. The KIE experiment
