1453491-84-3Relevant academic research and scientific papers
Chelation-Assisted Palladium-Catalyzed γ-Arylation of Aliphatic Carboxylic Acid Derivatives
Dey, Aniruddha,Pimparkar, Sandeep,Deb, Arghya,Guin, Srimanta,Maiti, Debabrata
, p. 1301 - 1307 (2017)
A palladium(II)-catalyzed protocol for the highly regioselective remote γ-C–H arylation of aliphatic carboxylic acid has been disclosed. The 8-aminoquinoline moiety as an intramolecular bidentate chelator was found to be suitable for this γ-C–H arylation. Various aryl iodides successfully produced the regioselectively mono-arylated products with negligible diarylation. Functional group tolerance and easy-to-handle reaction conditions make this method attractive. (Figure presented.).
Palladium-Catalyzed Base-Promoted Arylation of Unactivated C(sp3)–H Bonds by Aryl Iodides: A Practical Approach To Synthesize β-Aryl Carboxylic Acid Derivatives
Gou, Quan,Liu, Gang,Zhou, Lanxiu,Chen, Suiyun,Qin, Jun
, p. 6314 - 6318 (2017/11/21)
A highly efficient protocol for the β-arylation of carboxylic amides by aryl iodides under PdCl2(CH3CN)2/CsOAc catalysis was developed. This method was found to tolerate a broad scope of substrates and was successfully employed in the preparation of a variety of β-aryl α-amino and γ-amino acid derivatives. The utility of this method was further illustrated in the synthesis of the psychotropic drug (±)-phenibut and β-aryl bile acid analogues.
Palladium-catalyzed Cs2CO3-promoted arylation of unactivated C(sp3)-H bonds by (diacetoxyiodo)arenes: Shifting the reactivity of (diacetoxyiodo)arenes from acetoxylation to arylation
Gou, Quan,Zhang, Zhao-Fu,Liu, Zhi-Cheng,Qin, Jun
, p. 3176 - 3186 (2015/03/30)
PdCl2(CH3CN)2-catalyzed arylation of unactivated C(sp3)-H bonds using (diacetoxyiodo)arenes as arylation reagents is reported. The reactivity of (diacetoxyiodo)arenes as arylation reagents is enabled in the presence of Cs2CO3 under the reaction conditions. This arylation method is highly efficient and occurs without the use of silver salt. The reaction tolerates a broad substrate scope that was not demonstrated by other silver salt-free C(sp3)-H bond arylation conditions. The synthetic utility of the method is further illustrated in the synthesis of the psychotropic drug phenibut. A detailed mechanism study has been conducted to understand the reaction pathway.
