145350-27-2

Upstream product

• 132201-75-3 2,3,4,6-tetra-O-benzyl-D-glucopyranose trichloroacetimidate 
• 482582-70-7 4-[3-((2R,4aR,6S,7R,8S,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-prop-1-ynyl]-benzoic acid 
• 29600-81-5 methyl 2,3-di-O-benzyl-4,6-O-benzylidene-α-D-galactopyranoside 
• 114079-09-3 2,2,2-trichloroethyl 2,3-di-O-benzyl-α-D-mannopyranoside 
• 105165-52-4 2,2,2-trichloroethyl 2,3-di-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside 
• 137491-98-6 2,2,2-trichloroethyl 4,6-O-benzylidene-α-D-mannopyranoside 
• 100-39-0 benzyl bromide 
• 3006-41-5 (4aR,7R,8R,8aR)-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol 
• 10257-28-0 D-Galactose 
• 100-44-7 benzyl chloride 
• 4288-93-1 methyl 4,6-O-benzylidene-α-D-galactopyranoside 
• 482582-69-4 4-[3-((2R,4aR,6S,7R,8S,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-prop-1-ynyl]-benzoic acid methyl ester 
• 482582-68-3 2,3-di-O-benzyl-4,6-benzylidene-1-O-propynyl-α-D-glucopyranoside 
• 414858-63-2 propargyl 4,6-O-benzylidene-α-D-glucopyranoside 

Downstream Products

• 20770-84-7 2,3-di-O-benzyl-4,6-O-benzylidene-D-glucopyranose 
• 145350-29-4 O-(4,6-di-O-acetyl-2,3-di-O-benzyl-β-D-mannopyranosyl)-(1<*>4)-1,2,3,6-tetra-O-acetyl-α-D-glucopyranose 
• 145350-29-4 O-(4,6-di-O-acetyl-2,3-di-O-benzyl-β-D-mannopyranosyl)-(1<*>4)-1,2,3,6-tetra-O-acetyl-β-D-glucopyranose 
• 145350-28-3 2,3-di-O-acetyl-1,6-anhydro-4-O-(4,6-di-O-acetyl-2,3-di-O-benzyl-β-D-mannopyranosyl)-β-D-glucopyranose 
• 95504-11-3 1,4-di-O-acetyl-2,3-di-O-benzyl-α-D-mannopyranosyl bromide 
• 68536-42-5 acetyl 4,6-di-O-acetate-2,3-di-O-benzyl-α-D-mannopyranoside 

Relevant academic research and scientific papers

5-FLUORO-C-(ARYL OR HETEROCYCLYL)-GLYCOSIDE DERIVATIVES USEFUL AS DUAL SGLT1 / SGLT2 MODULATORS

The present invention is directed to 5-fluoro-C-(aryl or hetercyclyl)-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity.

Solid-phase synthesis of oligosaccharides using novel alkyne-type linkers: Selection of reactive sites on the support by Sonogashira reaction

Two new alkyne-type linkers having alkynylmethyloxy moieties were elaborated for solid-phase synthesis of oligosaccharides. A propargyl glycoside-type linker between a sugar residue and a solid support was formed by the Sonogashira reaction of a propargyl glycoside with polymer-supported iodobenzene. A propargyl ester-type linker was also constructed by the same reaction of a 4-(proparygyloxycarbonyl)benzyl glycoside with the latter. Both linkers are stable against acids such as TFA but can be readily cleaved with this acid after conversion to the corresponding alkyne-cobalt complex by treatment with C02(CO)8. The latter ester linker is generally advantageous in that mild cleavage liberates a product as its carboxybenzyl glycoside which is readily purified. The Sonogashira reaction was found to proceed only at spatially reactive sites on the solid support where the reagent accesses readily, so that the subsequent reactions including glycosylation on solid phase proceeded smoothly to result in high total yields of the desired oligosaccharides.

Synthetic studies on oligosaccharide of a glycolipid from the spermatozoa of bivalves. VII. The synthesis of di-, tri-, tetrasaccharides related to glycosphingolipid

The three kinds of oligosaccharides that constitute the partial structure of lipid IV (1) were synthesized as follows. The disaccharide O-β-D-mannopyranosyl-(1 → 4)-D-glucopyranose (13), the trisaccharide O-α-D-mannopyranosyl-(1 → 3)-O-β-D-mannopyranosyl-

ALKYLATION OF CARBOHYDRATES IN A CATALYTIC TWO-PHASE SYSTEM

Alkylation of hydroxyl groups of sugars has been performed by means of primary alkyl halides or sulfates in a catalytic two-phase (CTP) system containing a concentrated, aqueous sodium hydroxide solution and a catalyst, i.e. tetra-n-butylammonium chloride.The corresponding ethers were formed with a very high yield.