14537-59-8

Upstream product

• 19411-70-2 N-tert-butyl-N'-methylcarbodiimide 
• 20605-40-7 thiobenzoylhydrazine 
• 75-36-5 acetyl chloride 
• 28898-88-6 N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide 
• 74-88-4 methyl iodide 
• 72926-10-4 4-Acetyl-2-(acetylmethylamino)-5-phenyl-Δ²-1,3,4-thiadiazoline 
• 108-24-7 acetic anhydride 
• 1627-73-2 1-benzylidene thiosemicarbazide 
• 62236-01-5 2-(Acetamido)-4-acetyl-5-phenyl-Δ²-1,3,4-thiadiazoline 

Relevant academic research and scientific papers

NOVEL REARRANGEMENT OF 3-ACYL-5-ACYLAMINO-2,3-DIHYDRO-1,3,4-THIADIAZOLE 1-OXIDE INTO 1,3,4-OXADIAZOLES

Thermally, or in the presence of p-toluenesulfonic acid, 3-acyl-5-acylamino-2,3-dihydro-1,3,4-thiadiazole 1-oxides are transformed into 1,3,4-oxadiazoles, carbonyl compounds and sulfur.

Synthesis of 4-Acyl-2-(acylamino)-Δ2-1,3,4-thiadiazolines and 4-Acyl-2-amino-Δ2-1,3,4-thiadiazolines by Acylation of Thiosemicarbazones

Acylation of aldehyde and ketone thiosemicarbazones (2) with acid anhydrides or acid chlorides gave 4-acyl-2-(acylamino)-Δ2-1,3,4-thiadiazolines (3) in good yields.Treatment of 3 with hydrazine hydrate furnished the 2-amino derivatives (4).The 4-methylthiosemicarbazone of benzaldehyde underwent a similar cyclization with acetic anhydride to furnish the corresponding 2-(acetylmethylamino)thiadiazoline.