145372-96-9

Upstream product

• 3054-95-3 acrylaldehyde diethyl acetal 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 10602-03-6 ethyl 4-ethynylbenzoate 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 107-02-8 acrolein 
• 145372-94-7 4-(4H-[1,3]Dioxin-4-yl)-benzoic acid ethyl ester 

Downstream Products

• 1434058-00-0 ethyl 4-((1E,3Z)-hexa-1,3,5-trien-1-yl)benzoate 
• 1434057-95-0 ethyl 4-((1E,3E)-hexa-1,3,5-trien-1-yl)benzoate 
• 1415335-57-7 ((2S,3R,4S)-4-ethyl-3-(hydroxymethyl)-4-phenyl-2,3,4,9-tetrahydro-1H-carbazol-2-yl)benzoate 
• 1352922-01-0 ethyl 4-((1E,3E)-6,7-dimethylocta-1,3,6-trienyl)benzoate 
• 1352922-15-6 ethyl 4-((E)-5,6-dimethyl-3-methylenehepta-1,5-dienyl)benzoate 
• 1352921-98-2 (E)-ethyl 4-(buta-1,3-dien-1-yl)benzoate 

Relevant academic research and scientific papers

Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a π-Acceptor Biphosphoramidite Ligand

The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important E-(poly)enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.

Heck Reactions of Acrolein or Enones and Aryl Bromides – Synthesis of 3-Aryl Propenals or Propenones and Consecutive Application in Multicomponent Pyrazole Syntheses

3-(Hetero)aryl propenals or propenones are efficiently prepared by a Heck reaction of (hetero)aryl bromides and acrolein or vinyl ketones using Beller's CataCXium Ptb ligand under Jeffery's and Fu's conditions. The formation of these three-carbon building blocks is embedded into consecutive three- and pseudo-four-component syntheses of 3-(hetero)aryl and 3,5-diarylpyrazoles with a broad substitution pattern in moderate to excellent yield.

Cobalt-catalyzed 1,4-hydrobutadienylation of 1-aryl-1,3-dienes with 2,3-dimethyl-1,3-butadiene

Round and round the olefin goes! A cobalt-catalyzed 1,4- hydrobutadienylation of a 1-aryl-substituted 1,3-diene with 2,3-dimethyl-1,3- butadiene yields 1,3,6-triene derivatives in excellent yield and chemoselectivity. The application of a bulky ligand (SchmalzPhos) leads to the selective formation of a single regio- and stereoisomer. Copyright

An improved general method for palladium catalyzed alkenylations and alkynylations of aryl halides under microwave conditions

Palladium catalyzed facile method for alkenylation and alkynylation of arylhalides in good to excellent yield under microwave condition is reported.

An efficient palladium-catalyzed synthesis of cinnamaldehydes from acrolein diethyl acetal and aryl iodides and bromides

(Matrix presented) The reaction of aryl iodides and bromides with acrolein diethyl acetal in the presence of Pd(OAc)2, nBu 4NOAc, K2CO3, KCl, and DMF, at 90°C until the disappearance of the acetal followed by the addition of 2 N HCl to the crude reaction mixture, affords cinnamaldehydes in good to high yields. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, dialkylamino, nitrile, and nitro groups. The presence of substituents close to the oxidative addition site does not hamper the reaction.

THE PALLADIUM-CATALYZED ARYLATION OF 4-H-1,3-DIOXIN

4H-1,3-Dioxin was firstly arylated by using Heck reaction, and the reaction in the presence of (R)-BINAP gave enantiomerically enriched 4-phenyldioxin which was converted into optically active 1-phenyl-1,3-propanediol.