1453810-97-3Relevant academic research and scientific papers
Organocatalytic one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones
Pan, Gao-Fei,Su, Li,Zhang, Yan-Lei,Guo, Shi-Huan,Wang, Yong-Qiang
, p. 25375 - 25378 (2016/03/22)
A highly efficient organocatalytic one-pot enantioselective synthesis of (R)-2-aryl-2,3-dihydro-4-quinolones from o-aminoacetophenones and aryl aldehydes has been developed. The approach is characterized by being metal free, solvent free and protecting group free. A variety of 2-aryl-2,3-dihydro-4-quinolones could be obtained in good yields up to 99% ee.
Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones
Mondal, Buddhadeb,Pan, Subhas Chandra
supporting information, p. 9789 - 9792 (2015/01/09)
Primary amino acids are found to be good enantioselective catalysts for the direct asymmetric Mannich reaction between 2-amino acetophenone and aldehydes. The 2-aryl-2,3-dihydro-4-quinoline products are obtained in moderate to good yields and good to high enantioselectivities with 10 mol% of the primary amino acid catalyst under mild reaction conditions.
One-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones catalyzed by amino acid-derived sulfonamides
Zheng, Haixing,Liu, Qi,Wen, Saishuai,Yang, Hua,Luo, Yiming
, p. 875 - 882 (2013/09/23)
An organocatalyzed approach to the asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones using amino-acid derived sulfonamides as organocatalysts, which can be easily prepared starting from l-proline, l-alanine, and l-phenylalanine, has been developed i
