1453811-40-9Relevant academic research and scientific papers
Cu-mediated 1,3-dipolar cycloaddition of azomethine ylides with dipolarophiles: A faster access to spirooxindoles of potential pharmacological interest
Singh, Shambhu Nath,Regati, Sridhar,Paul, Abir Kumar,Layek, Mohosin,Jayaprakash, Sarva,Reddy, K. Venkateshwara,Deora, Girdhar Singh,Mukherjee, Soumita,Pal, Manojit
, p. 5448 - 5452 (2013)
CuI facilitated three-component reaction of isatin derivatives, l-proline and terminal alkynes containing an amide or ester functional group. The multi-component reaction (MCR) afforded a faster and practical synthesis of spirooxindole derivatives. A range of novel spirooxindoles were synthesized by using this straightforward and one-pot efficient methodology. A representative compound showed significant inhibition of PDE4B enzyme in vitro and good interactions with this protein in silico.
