1453837-63-2Relevant academic research and scientific papers
Expanding the scope of the asymmetric anti-aldol addition of chiral N-amino cyclic carbamate hydrazones
Knight, John D.,Coltart, Don M.
, p. 5470 - 5472 (2013)
An asymmetric anti-aldol addition process of ketone-derived donors that is not limited by the structure of the ketone is described. This is achieved by merging the enantioselective α,α-bisalkylation of N-amino cyclic carbamate (ACC) hydrazones with the asymmetric anti-aldol addition of ACC hydrazones. The products of this process are obtained with essentially perfect stereoselectivity. Using this procedure it is possible to gain access to ketone-based anti-aldol addition products that are inaccessible in a controlled sense via direct aldol methods.
