1453841-50-3Relevant academic research and scientific papers
Mild and general conditions for Negishi cross-coupling enabled by the use of palladacycle precatalysts
Yang, Yang,Oldenhuis, Nathan J.,Buchwald, Stephen L.
supporting information, p. 615 - 619 (2013/02/23)
A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd0 species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields. Copyright
