145385-67-7Relevant academic research and scientific papers
STEROIDAL SAPONINS FROM tHE RHIZOMES OF SMILAX SIEBOLDII
Kubo, Satoshi,Mimaki, Yoshihiro,Sashida, Yutaka,Nikaido, Tamotsu,Ohmoto, Taichi
, p. 2445 - 2450 (1992)
Six new steroidal saponins were isolated from the rhizomes of Smilax sieboldii.Their structures were determined by spectroscopic analysis and hydrolysis to be 3β-hydroxy-(25R)-5α-spirostan-6-one (laxogenin) 3-O-β-D-glucopyranosyl-(14-O-6)>-β-D-glucopyranoside, laxogenin 3-O-α-L-arabinopyranosyl-(16)-β-D-glucopyranoside, 3β,27-dihydroxy-(25S)-5α-spirostan-6-one 3-O-β-D-glucopyranosyl-(14)-O-6)>-β-D-glucopyranoside, 26-O-β-D-glucopyranosyl-3β,22ξ,26-trihydroxy-(25R)-5α-furostan-6-one 3-O-α-L-arabinopyranosyl-(16)-β-D-glucopyranoside, 26-O-β-D-glucopyranosyl-3β,22ξ,26-trihydroxy-(25R)-5α-furostan-6-one 3-O-β-D-glucopyranosyl-(14)-O-6)>-β-D-glucopyranoside and (25R)-5α-spirostan-3β-ol (tigogenin) 3-O-β-D-glucopyranosyl-(14)-O-6)>-β-D-glucopyranoside.The inhibition of cAMP phosphodiesterase by the saponins was evaluated. Key Word Index - Smilax sieboldii; Liliaceae; steroidal saponins; spirostanol glycosides; furostanol glycosides; laxogenin glycosides; tigogenin glycoside; cAMP phosphdiesterase; inhibitory activity.
