STEROIDAL SAPONINS FROM tHE RHIZOMES OF SMILAX SIEBOLDII

Article abstract of DOI:10.1016/0031-9422(92)83296-B

Six new steroidal saponins were isolated from the rhizomes of Smilax sieboldii.Their structures were determined by spectroscopic analysis and hydrolysis to be 3β-hydroxy-(25R)-5α-spirostan-6-one (laxogenin) 3-O-β-D-glucopyranosyl-(1<*>4-O-<α-L-arabinopyranosyl-(1<*>6)>-β-D-glucopyranoside, laxogenin 3-O-α-L-arabinopyranosyl-(1<*>6)-β-D-glucopyranoside, 3β,27-dihydroxy-(25S)-5α-spirostan-6-one 3-O-β-D-glucopyranosyl-(1<*>4)-O-<α-L-arabinopyranosyl-(1<*>6)>-β-D-glucopyranoside, 26-O-β-D-glucopyranosyl-3β,22ξ,26-trihydroxy-(25R)-5α-furostan-6-one 3-O-α-L-arabinopyranosyl-(1<*>6)-β-D-glucopyranoside, 26-O-β-D-glucopyranosyl-3β,22ξ,26-trihydroxy-(25R)-5α-furostan-6-one 3-O-β-D-glucopyranosyl-(1<*>4)-O-<α-L-arabinopyranosyl-(1<*>6)>-β-D-glucopyranoside and (25R)-5α-spirostan-3β-ol (tigogenin) 3-O-β-D-glucopyranosyl-(1<*>4)-O-<α-L-arabinopyranosyl-(1<*>6)>-β-D-glucopyranoside.The inhibition of cAMP phosphodiesterase by the saponins was evaluated. Key Word Index - Smilax sieboldii; Liliaceae; steroidal saponins; spirostanol glycosides; furostanol glycosides; laxogenin glycosides; tigogenin glycoside; cAMP phosphdiesterase; inhibitory activity.