1453863-35-8

Basic information

• Product Name: (R,E)-tert-butyl (1-cinnamyl-3-cyano-2-oxoindolin-3-yl)carbamate
• Synonyms: (R,E)-tert-butyl (1-cinnamyl-3-cyano-2-oxoindolin-3-yl)carbamate
• CAS NO: 1453863-35-8
• Molecular Weight: 389.454
• Mol File: 1453863-35-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,E)-tert-butyl (1-cinnamyl-3-cyano-2-oxoindolin-3-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R,E)-tert-butyl (1-cinnamyl-3-cyano-2-oxoindolin-3-yl)carbamate(1453863-35-8)
• EPA Substance Registry System: (R,E)-tert-butyl (1-cinnamyl-3-cyano-2-oxoindolin-3-yl)carbamate(1453863-35-8)

Safety Data

• Hazardous Substances Data: 1453863-35-8(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 

Relevant articles and documents

The quinine thiourea-catalyzed asymmetric Strecker reaction: An approach for the synthesis of 3-aminooxindoles

An organocatalytic enantioselective Strecker reaction for the synthesis of 3-amino-3-cyanooxindoles has been developed. Employing a quinine-derived thiourea catalyst, the nucleophilic addition of trimethylsilyl cyanide to N-Boc-ketimines affords 3-amino-3-canooxindoles in good to excellent yields (78-98%) and very good enantioselectivities (up to 94%). Furthermore, to the best of our knowledge, this method also represents the first enantioselective organocatalyzed Strecker reaction with N-Boc-ketimines as electrophiles.