1453873-65-8

Upstream product

• 108-94-1 cyclohexanone 
• 61045-33-8 diethyl (2R,3R)-1,4-dioxaspiro[4.5]decane-2,3-dicarboxylate 
• 114026-76-5 (-)-(2R,3R)-trans-2,3-bis(hydroxydiphenylmethyl)-1,4-dioxaspiro[4.5]decane 
• 1453873-64-7 C₃₄H₃₂N₆O₂ 
• 114128-87-9 (2R,3R)-(–)-1,4-dioxaspiro[4.5]decane-2,3-dicarboxylic acid dimethyl ester 

Downstream Products

• 1609262-63-6 C₄₉H₅₅N₃O₂*ClH 
• 1453873-46-5 C₄₉H₅₅N₃O₂ 

Relevant academic research and scientific papers

Based on the chiral diamine spiro skeleton chiral phosphorus nitrile catalyst, preparation method and application thereof

The invention provides a chiral phosphazene catalyst based on a spiro framework adopting chiral diamine, a preparation method and an application of the chiral phosphazene catalyst. The catalyst has a structure represented in the general formula: (RX-)3P=NR', chiral groups are introduced through R and R', and the catalyst has a structure with two seven-membered rings in centered connection through phosphorspirol. Optically pure tartaric acid or substituted hexahydrophthalic acid or 1,2-cyclopentanedicarboxylicacid,(1R,2S)-rel- is taken as a raw material, chiral diamine is generated through esterification, a Grignard reaction, an optional chlorination reaction, an azido reaction and a reduction reaction of the raw material, then chiral diamine and phosphorus pentachloride have a spirocyclization reaction to construct a phosphorspirol-centered screw ring, the chiral phosphazene molecular catalyst is obtained under the alkaline condition, and a method for substituting azido for hydroxyl directly has good application and popularization value. The catalyst has the advantages of high catalysis efficiency, good stereoselectivity, mild conditions, economy, environmental protection, simplicity and convenience in operation and the like as well as popularization and application prospects.

Novel tartrate-derived guanidine-catalyzed highly enantio- and diastereoselective Michael addition of 3-substituted oxindoles to nitroolefins

The Michael addition of 3-substituted oxindoles to nitroolefins was catalyzed by a novel tartrate-derived guanidine in high yield with excellent diastereo- and enantioselectivity. This method showed an extraordinarily broad substrate scope in terms of both reaction partners. the Partner Organisations 2014.