145449-69-0Relevant academic research and scientific papers
NEW SYNTHESIS OF IMIDAZO- AND PYRIMIDOPYRIMIDINES
Abdel-Fattah, A. M.,Sherif, S. M.,El-Reedy, A. M.,Gad-Alla, S. A.
, p. 67 - 74 (2007/10/02)
6-Aryl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles (1) reacted with bromomalonitrile (2) to give 3-amino-7-aryl-5-oxo-5H-thiazolopyrimidine-2,6-dicarbonitriles (3a-c).The latter compounds reacted with either formic acid, formamide or ammonium thiocyanate to yield the 7-aryl-9-oxo-4-substituted-thiazolodipyrimidine-8-carbonitrile derivatives (4-6), respectively.Compounds (3a-c) could be converted into 7-aryl-3-amino-1-benzyl-5-oxo-5H-imidazolpyrimidine-6-carbonitriles (8) and4-amino-8-aryl-2,6-dioxo-3-substituted-1,2-dihydro-6H-pyrimidopyrimidine-7-carbonitriles (9) by treatment in boiling ethanol with benzylamine and cyclic secondary amines, respectively. Key words: Imidazo and pyrimidopyrimidine.
