1454574-39-0

Upstream product

• 22889-78-7 3,5-dichloro-4-aminopyridine 
• 1454798-33-4 C₁₄H₁₈F₂O₄ 
• 151103-09-2 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde 

Downstream Products

• 162401-32-3 roflumilast 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF ROFLUMILAST

The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

PROCESS FOR PREPARATION OF ROFLUMILAST

The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

PREPARATION METHOD OF ROFLUMILAST

The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: (formula) In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.