22889-78-7

Basic information

• Product Name: 4-Amino-3,5-dichloropyridine
• Synonyms: 4-AMINO-3,5-DICHLOROPYRIDINE, 98+%;4-Amino-3,5-Dichloropyridine 99%;4-Amino-3,5-dichloropyridin-4-amine;4- aMino-3,5- twochlorine pyridine;AMino - 4-3, 5 - dichloro pyridine;4-Amino-3,5-dichloropyridine 3,5-Dichloro-4-pyridinamine;Roflumilast Imp.C;AURORA 23319
• CAS NO: 22889-78-7
• Molecular Formula: C₅H₄Cl₂N₂
• Molecular Weight: 163
• EINECS: 245-304-6
• Product Categories: pharmacetical;Amines;Pyridines;Chloropyridines;Halopyridines;Boronic Acid;Roflumilast interemdiate;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines
• Mol File: 22889-78-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 159°C
• Boiling Point: 250.8 °C at 760 mmHg
• Flash Point: 105.5 °C
• Appearance: /
• Density: 1.497 g/cm³
• Vapor Pressure: 0.0212mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 1.48±0.10(Predicted)
• BRN: 120547
• CAS DataBase Reference: 4-Amino-3,5-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3,5-dichloropyridine(22889-78-7)
• EPA Substance Registry System: 4-Amino-3,5-dichloropyridine(22889-78-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 22889-78-7(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline powder

Uses

4-Amino-3,5-dichloropyridine is a metabolite of the selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).

InChI:InChI=1/C5H4Cl2N2/c6-3-1-9-2-4(7)5(3)8/h1-2H,(H2,8,9)/p+1

Synthetic route

4-aminopyridine (504-24-5) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
Stage #1: 4-aminopyridine With hydrogenchloride; dihydrogen peroxide In water at 10 - 72℃; for 3.25h; Stage #2: With sodium hydroxide In water at 45℃; for 0.5h; pH=9 - 10; Reagent/catalyst; Temperature;	92.7%
With hydrogenchloride; dihydrogen peroxide
With aqueous hydrogen peroxide In concentrated hydrochloric acid

3,3,5,5-tetrachloropiperidin-4-one → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
With ammonia In methanol at 40 - 45℃; for 4h; Autoclave;	89.7%

3,5-dichloropyridine-4-carbonitrile (153463-65-1) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
With lithium amide In ammonia 0 deg C to RT;	54%

4-amino-3-chloropyridine (19798-77-7) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
With hydrogenchloride; dihydrogen peroxide

3,4,5-trichloropyridine (33216-52-3) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
With ammonium hydroxide at 150℃; im Rohr;

4-amino-3,5-dichloro-pyridine-2-carboxylic acid (17122-17-7) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
Erhitzen ueber den Schmelzpunkt;

3.5-dichloro-4-amino-picolinic acid → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
beim Erhitzen ueber den Schmelzpunkt;

3,4,5-trichloropyridine (33216-52-3) + ammonia (7664-41-7) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
at 150℃; im Rohr;

4-aminopyridine (504-24-5) + hydrogenchloride (7647-01-0) + water (7732-18-5) + dihydrogen peroxide (7722-84-1) → 3,5-dichloro-4-aminopyridine (22889-78-7)

hydrogenchloride (7647-01-0) + 4-(nitroamino)pyridine (26482-55-3) → 4-Chloropyridine (626-61-9) + 3,4,5-trichloropyridine (33216-52-3) + 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
at 100℃;

3-amino-4-chloropyridine (20511-15-3) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium nitrite; copper-powder; aqueous hydrochloric acid / Diazotization 2: aqueous NH3 / 190 °C 3: concentrated aqueous HCl; aqueous H2O2 View Scheme

3,4-dichloropyridine (55934-00-4) → 3,5-dichloro-4-aminopyridine (22889-78-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NH3 / 190 °C 2: concentrated aqueous HCl; aqueous H2O2 View Scheme

3-benzoyloxy-4-methoxybenzoyl chloride (144036-22-6) → 3,5-dichloro-4-aminopyridine (22889-78-7) + N-(3,5-dichloropyrid-4-yl)-3-benzoyloxy-4-methoxybenzamide (159782-90-8)

3,5-dichloro-4-aminopyridine (22889-78-7) → 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy) phenoxy]pentanoic acid (1422361-76-9)

Conditions	Yield
With thionyl chloride In tetrahydrofuran; toluene	96.45%

3,5-dichloro-4-aminopyridine (22889-78-7) + 2-(3-benzyloxy-propyl)-3,4-dimethoxy-benzoic acid (1006612-51-6) → 2-(3-benzyloxy-propyl)-N-(3,5-dichloro-pyridin-4-yl)-3,4-dimethoxy-benzamide (1006612-52-7)

Conditions	Yield
Stage #1: 2-(3-benzyloxy-propyl)-3,4-dimethoxy-benzoic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 40℃; for 2h; Stage #2: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran at 20 - 30℃; for 3.5h;	96%

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid (162401-62-9) + 3,5-dichloro-4-aminopyridine (22889-78-7) → roflumilast (162401-32-3)

Conditions	Yield
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With pyridine; 2,4,6-trinitrochlorobenzene In 1,4-dioxane at 20 - 35℃; for 3h; Industrial scale; Stage #2: 3,5-dichloro-4-aminopyridine In 1,4-dioxane for 2h; Reagent/catalyst; Solvent; Temperature; Industrial scale;	95%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 0 - 20℃; for 3h; Stage #2: 3,5-dichloro-4-aminopyridine In dichloromethane for 2h; Concentration;	91%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With pivaloyl chloride; sodium carbonate In tetrahydrofuran at 25℃; for 2h; Stage #2: 3,5-dichloro-4-aminopyridine In tetrahydrofuran at 50℃; for 4h; Temperature; Solvent; Reagent/catalyst;	64%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With thionyl chloride In toluene Heating / reflux; Stage #2: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran for 1h; Cooling;	58.6%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3-(difluoromethoxy)-4-(cyclopropylmethoxy)-benzoic acid (162401-69-6) → roflumilast (162401-32-3)

Conditions	Yield
Stage #1: 3-(difluoromethoxy)-4-(cyclopropylmethoxy)-benzoic acid With thionyl chloride In toluene for 2h; Reflux; Stage #2: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran at 15 - 20℃;	95%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3-Phenylpropionic acid (501-52-0) → N-(3,5-dichloropyridin-4-yl)-3-phenylpropanamide (1370286-81-9)

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;	93%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;	93.3%

3,5-dichloro-4-aminopyridine (22889-78-7) + 4-nitrophenyl 8-methoxy-2,9-dimethyl-1-oxo-1,2,3,4-tetrahydro-β-carboline-5-carboxylate (893555-73-2) → N-(3,5-dichloropyridin-4-yl)-2,9-dimethyl-8-methoxy-1-oxo-1,2,3,4-tetrahydro-β-carboline-5-carboxamide

Conditions	Yield
With sodium hydride at 20℃; for 18h;	90%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 18h;

3,5-dichloro-4-aminopyridine (22889-78-7) + (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-imidazol-1-yl)methanone (1590361-85-5) → roflumilast (162401-32-3)

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With cesium fluoride In dimethyl sulfoxide at 90℃; for 3h; Stage #2: (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-imidazol-1-yl)methanone In dimethyl sulfoxide at 90 - 95℃; for 6.5h; Reagent/catalyst;	88%

3,5-dichloro-4-aminopyridine (22889-78-7) + p-nitrophenyl 4-difluormethoxy-8-nitrodibenzofuran carboxylic acid ester (883977-47-7) → N-(3,5-dichloro-pyridin-4-yl)-4-difluoromethoxy-8-nitro-dibenzo[b,d]furane-1-carboxamide (685875-02-9)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 25 - 35℃; for 1.83333 - 1.91667h;	86%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3,4-bis(cyclopropylmethoxy)benzoyl chloride (669001-67-6) → 3,4-bis(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl) benzamide

Conditions	Yield
With sodium hydride In acetonitrile at -5 - 0℃; for 1h;	85.3%

3,5-dichloro-4-aminopyridine (22889-78-7) + C17H10F2N2O2S → 3,5-dichloro-4-(4-difluoromethoxy-dibenzo[b,d]-thiophen-1-yl-carboxamido)pyridine

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h; Stage #2: C17H10F2N2O2S In DMF (N,N-dimethyl-formamide)	85%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3-cyclopentyloxy-4-methoxy benzoic acid chloride (144036-19-1) → piclamilast (144035-83-6)

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With potassium tert-butylate In toluene at 90℃; Green chemistry; Stage #2: 3-cyclopentyloxy-4-methoxy benzoic acid chloride In toluene for 1h; Reagent/catalyst; Temperature; Solvent; Reflux; Green chemistry;	84%
With sodium hydride 1.) THF, 0.25 h, 2.) THF, RT, 0.5 h; Yield given. Multistep reaction;

3,5-dichloro-4-aminopyridine (22889-78-7) + 7-methoxy-2-phenethyl-benzofuran-4-carbonyl chloride → 7-methoxy-2-phenethyl-benzofuran-4-carboxylic acid (3,5-dichloropyridin-4-yl)-amide

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With sodium aluminum diethyl dihydride In tetrahydrofuran; toluene at 50℃; for 1h; Metallation; Stage #2: 7-methoxy-2-phenethyl-benzofuran-4-carbonyl chloride In tetrahydrofuran; toluene at 50℃; for 2h; Acylation;	80%

3,5-dichloro-4-aminopyridine (22889-78-7) + 4-(difluoromethoxy)benzoyl chloride (57320-63-5) → N-(3,5-dichloro-4-pyridyl)-4-(difluoromethoxy)benzamide

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst;	80%

3,5-dichloro-4-aminopyridine (22889-78-7) + (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone (1601300-21-3) → roflumilast (162401-32-3)

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With cesium fluoride In dimethyl sulfoxide at 90℃; for 3h; Stage #2: (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-1,2,4-triazol-1-yl)methanone In dimethyl sulfoxide at 90 - 95℃; for 3h;	79%

3,5-dichloro-4-aminopyridine (22889-78-7) + 4-methoxy-2-methylsulfanylpyrimidine-5-carboxylic acid (84332-06-9) → N-(3,5-dichloropyridin-4-yl)-4-methoxy-2-(methylthio)pyrimidine-5-carboxamide

Conditions	Yield
Stage #1: 4-methoxy-2-methylsulfanylpyrimidine-5-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 5h; Stage #2: 3,5-dichloro-4-aminopyridine With sodium hydride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 2h;	75.06%

2-(cyclopentyloxy)-4-iodo-1-methoxybenzene (651023-32-4) + 3,5-dichloro-4-aminopyridine (22889-78-7) + 13C-methyldiphenylsilanecarboxylic acid (1346220-47-0) → C17(13)CH18Cl2N2O3 (1346220-48-1)

Conditions	Yield
Stage #1: 13C-methyldiphenylsilanecarboxylic acid With potassium fluoride In toluene at 70℃; Inert atmosphere; Stage #2: 2-(cyclopentyloxy)-4-iodo-1-methoxybenzene; 3,5-dichloro-4-aminopyridine With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; catacxium A In toluene at 70℃; for 21h; Inert atmosphere;	74%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde (151103-09-2) → 3,5-dichloro-N-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzylidene)pyridin-4-amine (1454574-39-0)

Conditions	Yield
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With trifluoroacetic acid; trimethyl orthoformate In toluene at 20 - 30℃; Inert atmosphere; Reflux; Stage #2: 3,5-dichloro-4-aminopyridine With trifluoroacetic acid In toluene at 40 - 110℃;	73%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With toluene-4-sulfonic acid; trimethyl orthoformate In toluene for 3h; Reflux; Stage #2: 3,5-dichloro-4-aminopyridine With toluene-4-sulfonic acid In toluene at 70 - 80℃; for 30h; Reflux;	23%
With N,O-Bis(trimethylsilyl)trifluoroacetamide; toluene-4-sulfonic acid In acetonitrile for 48h; Reagent/catalyst; Reflux;	70 %Chromat.

3,5-dichloro-4-aminopyridine (22889-78-7) + tert-butyl 4-(4-(2,5-dichloro-4-pyrimidinyl)amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate → 5-chloro-N2(3,5-dichloropyridin-4-yl)-N4(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)pyrimidine-2,4-diamine

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol at 80℃;	72.9%

3,5-dichloro-4-aminopyridine (22889-78-7) + 1-(4-fluorobenzyl)-7-azaindol-3-yl-glycoxylic acid chloride → AWD-12-353

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran at -5 - 20℃; for 1h; Stage #2: 1-(4-fluorobenzyl)-7-azaindol-3-yl-glycoxylic acid chloride In tetrahydrofuran at 0℃; for 4h; Product distribution / selectivity; Reflux;	72%

3,5-dichloro-4-aminopyridine (22889-78-7) + C49H77N5O15S (1006612-69-6) → C54H79Cl2N7O14S (1006612-25-4)

Conditions	Yield
With water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at -5 - 25℃; for 4h;	70%

3,5-dichloro-4-aminopyridine (22889-78-7) + bis(trichloromethyl) carbonate (32315-10-9) + 4-amino-6-(3-bromophenyl)-2-ethylpyridazin-3(2H)-one (1229442-28-7) → 1-(6-(3-bromophenyl)-2-ethyl-3-oxo-2,3-dihydropyridazin-4-yl)-3-(3,5-dichloropyridin-4-yl)urea (1229442-29-8)

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; 4-amino-6-(3-bromophenyl)-2-ethylpyridazin-3(2H)-one With triethylamine In dichloromethane for 3h; Inert atmosphere; Stage #2: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran at 20℃;	70%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → N-(3,5-dichloropyridin-4-yl)-3,4,5-trimethoxybenzamide (1349175-46-7)

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With potassium 2-methylbutan-2-olate In toluene at 90℃; for 0.5h; Stage #2: for 0.5h; Reflux; Stage #3: 3,4,5-Trimethoxybenzoyl chloride Further stages;	70%
Stage #1: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere; Stage #2: 3,4,5-Trimethoxybenzoyl chloride In tetrahydrofuran at 0 - 20℃; for 24h; Inert atmosphere;	54%

3,5-dichloro-4-aminopyridine (22889-78-7) + C16H10F3N3O5 (1009603-03-5) → 7-methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridine-4-carboxylic acid (3,5-dichloro pyridin-4-yl)amide (1009601-54-0)

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: C16H10F3N3O5 In N,N-dimethyl-formamide at 0 - 20℃; for 3h;	70%

3,5-dichloro-4-aminopyridine (22889-78-7) + C16H10F3N3O5 → N-(3,5-dichloropyridin-4-yl)-7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine-3-carboxamide (1454802-94-8)

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: C16H10F3N3O5 In N,N-dimethyl-formamide at 0 - 20℃; for 3h;	70%

3,5-dichloro-4-aminopyridine (22889-78-7) → methyl 4-(5-((3,5-dichloropyridin-4-yl)carbamoyl)-2-(difluoromethoxy)phenoxy)benzoate (1422361-57-6)

Conditions	Yield
	70%

3,5-dichloro-4-aminopyridine (22889-78-7) + C13H10BrN3O2 → 1-(6-(3-bromophenyl)-2-ethyl-3-oxo-2,3-dihydropyridazin-4-yl)-3-(3,5-dichloropyridin-4-yl)urea (1229442-29-8)

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran for 2.5h; Stage #2: C13H10BrN3O2 In tetrahydrofuran at 20℃;	70%

3,5-dichloro-4-aminopyridine (22889-78-7) + 2-benzyl-7-methoxy-benzofuran-4-carbonyl chloride → 2-benzyl-7-methoxy-benzofuran-4-carboxylic acid (3,5-dichloropyridin-4-yl)-amide

Conditions	Yield
Stage #1: 3,5-dichloro-4-aminopyridine With sodium aluminum diethyl dihydride In tetrahydrofuran; toluene at 50℃; for 1h; Metallation; Stage #2: 2-benzyl-7-methoxy-benzofuran-4-carbonyl chloride In tetrahydrofuran; toluene at 50℃; for 2h; Acylation;	67%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 3,5-dichloro-4-aminopyridine (22889-78-7) → 3,5-dichloro-4-(1H-pyrrol-1-yl)pyridine

Conditions	Yield
With acetic acid at 120℃; for 0.333333h; Inert atmosphere;	63%

Upstream product

• 504-24-5 4-aminopyridine 
• 19798-77-7 4-amino-3-chloropyridine 
• 33216-52-3 3,4,5-trichloropyridine 
• 7664-41-7 ammonia 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 7722-84-1 dihydrogen peroxide 
• 26482-55-3 4-(nitroamino)pyridine 
• 144036-22-6 3-benzoyloxy-4-methoxybenzoyl chloride 
• 55934-00-4 3,4-dichloropyridine 
• 20511-15-3 3-amino-4-chloropyridine 
• 153463-65-1 3,5-dichloropyridine-4-carbonitrile 
• 17122-17-7 4-amino-3,5-dichloro-pyridine-2-carboxylic acid 

Downstream Products

• 17228-71-6 3,5-dichloro-4-hydroxypyridine 
• 185400-42-4 2-butyl-7-methoxy-benzofuran-4-carboxylic acid (3,5-dichloropyridin-4yl)-amide 
• 736970-88-0 N-{[(3,5-dichloro(4-pyridyl))amino]thioxomethyl}benzamide 
• 159782-49-7 N-(3,5-dichloropyrid-4-yl)-N'-(3-cyclopentyloxy-4-methoxyphenyl)urea 
• 1006612-52-7 2-(3-benzyloxy-propyl)-N-(3,5-dichloro-pyridin-4-yl)-3,4-dimethoxy-benzamide 
• 638219-46-2 N-(3,5-dichloro-pyridin-4-yl)-3-{3'-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-biphenyl-4-yl}-acrylamide 
• 656237-85-3 N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide 
• 1088496-40-5 C₃₂H₂₂Cl₂N₆O₅S 
• 1176169-45-1 3-(2-chloro-ethoxy)-N-(3,5-dichloro-pyridin-4-yl)-4-methoxy-benzamide 
• 1229442-29-8 1-(6-(3-bromophenyl)-2-ethyl-3-oxo-2,3-dihydropyridazin-4-yl)-3-(3,5-dichloropyridin-4-yl)urea 
• 913985-11-2 3-(tert-butyl-dimethyl-silanyloxy)-N-(3,5-dichloro-pyridin-4-yl)-4-methoxy-benzamide 

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