1454585-28-4Relevant academic research and scientific papers
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties
Bibian, Mathieu,Rahaim, Ronald J.,Choi, Jun Yong,Noguchi, Yoshihiko,Schürer, Stephan,Chen, Weimin,Nakanishi, Shima,Licht, Konstantin,Rosenberg, Laura H.,Li, Lin,Feng, Yangbo,Cameron, Michael D.,Duckett, Derek R.,Cleveland, John L.,Roush, William R.
, p. 4374 - 4380 (2013)
The development of a series of potent and highly selective casein kinase 1δ/ε (CK1δ/ε) inhibitors is described. Starting from a purine scaffold inhibitor (SR-653234) identified by high throughput screening, we developed a series of potent and highly kinas
WEE1 DEGRADATION INHIBITORS
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Page/Page column 75; 76, (2013/09/12)
The invention provides compounds that inhibit the degradation of Weel. The compounds of the present invention are generally N-((1H-benzo[d]imidazol-2- yl)methyl)-9H-purin-6-amines. Compounds of the invention can be used for treatment of malconditions in p
NOVEL SUBSTITUTED NITROGEN-CONTAINING HETEROBICYCLES AND USE THEREOF AS FACTOR XA INHIBITORS
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Page/Page column 115-116, (2008/06/13)
The invention relates to novel substituted nitrogen-containing heterobicycles of general formula (I), wherein B, X1 to X3, and R1 to R5 are defined as indicated in claim 1, the tautomers, enantiomers, diastereom
NOVEL CARBOXAMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS
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Page/Page column 150, (2010/02/07)
The invention relates to novel substituted carboxamides of general formula (I), in which A, B and R1 to R5 are as defined in claim 1, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, in particular the physiologi
