1454681-23-2Relevant academic research and scientific papers
A sort synthesis of polyhydroxylated pyrrolizidines via sequential 1,3-dipolar cycloaddition and reductive amination
Gkizis, Petros,Argyropoulos, Nikolaos G.,Coutouli-Argyropoulou, Evdoxia
, p. 8921 - 8928 (2013/09/23)
Polyhydroxylated pyrrolizidines bearing a methyl group at C-5 have been synthesized by 1,3-dipolar cycloaddition of five membered cyclic nitrones with methyl vinyl ketone followed by a N-O reductive cleavage and in situ intramolecular reductive amination. The stereochemistry of the obtained compounds is examined in relation to the reactions mechanism.
